CALCIUM HYDROXYAPATITE CERAMIC USED AS A DELIVERY SYSTEM FOR ANTIBIOTICS
CALCIUM HYDROXYAPATITE CERAMIC USED AS A DELIVERY SYSTEM FOR ANTIBIOTICS
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DOI：
10.1302/0301-620x.74b4.1320622
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发表时间：
1992-07-01
影响因子：
--
通讯作者：
ONO, K
中科院分区：
文献类型：
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作者：
SHINTO, Y;UCHIDA, A;ONO, K
评价了钙羟基磷灰石陶瓷多孔块作为抗生素缓释递送系统的效果。我们测试了硫酸庆大霉素，头孢哌酮钠，氟氧头孢钠粉末形式放置在一个圆柱形的空腔中的钙羟基磷灰石块，使用在体外研究的洗脱和在大鼠体内的研究。硫酸庆大霉素在第一周内给出了一个最大的浓度，逐渐下降，但仍然有效，在12周时，70%的抗生素已被释放。即使在这个阶段，75 mg剂量的抗生素浓度也是葡萄球菌最低抑菌浓度的5倍。在体内研究中，硫酸庆大霉素释放到大鼠正常骨中的速率和水平相似。药物的杀菌活性不受填充到钙羟基磷灰石陶瓷和块是完全生物相容的组织学上。这种新的系统克服了其他药物输送系统的缺点，避免了热损伤的抗生素和二次手术的载体去除。陶瓷提供了一定的机械强度，骨长入其微孔可加速加热。
Porous blocks of calcium hydroxyapatite ceramic were evaluated as delivery systems for the sustained release of antibiotics. We tested gentamicin sulphate, cefoperazone sodium, and flomoxef sodium in powder form placed in a cylindrical cavity in calcium hydroxyapatite blocks, using in vitro studies of elution and in vivo studies in rats.Gentamicin sulphate gave a maximum concentration within the first week, which gradually decreased but was still effective at 12 weeks, when 70% of the antibiotic had been released. Even at this stage the antibiotic concentration from a 75 mg dose was five times the minimum inhibitory concentration for staphylococci. In the in vivo studies the release of gentamicin sulphate into the normal bone of rats was at similar rates and levels. The bacteriocidal activity of the drugs was not affected by packing into calcium hydroxyapatite ceramic and the blocks were completely biocompatible on histology.This new system overcomes the disadvantages of other drug delivery systems, avoiding thermal damage to the antibiotics and a second operation for the removal of the carrier. Some mechanical strength is provided by the ceramic and heating may be accelerated by bone ingrowth into its micropores.