WALTZ-DB: a benchmark database of amyloidogenic hexapeptides
WALTZ-DB: a benchmark database of amyloidogenic hexapeptides
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DOI：
10.1093/bioinformatics/btv027
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发表时间：
2015-05-15
期刊：
影响因子：
5.8
通讯作者：
Schymkowitz, Joost
中科院分区：
文献类型：
--
作者：
Beerten, Jacinte;Van Durme, Joost;Schymkowitz, Joost
准确预测淀粉样蛋白形成氨基酸序列仍然是一个重要的挑战。我们在这里提出了一个在线数据库，提供了最大的实验特征的淀粉样蛋白形成六肽的开放访问。为此，我们扩大了我们以前的一组280 hexapeptides用于开发的华尔兹算法与89肽从文献综述和系统的实验表征的聚集720 hexapeptides的透射电子显微镜，染料结合和傅立叶变换红外光谱。这使得WALTZ-DB数据库中实验表征的六肽的总数达到1089个，其中244个被注释为淀粉样蛋白形成阳性。
Accurate prediction of amyloid-forming amino acid sequences remains an important challenge. We here present an online database that provides open access to the largest set of experimentally characterized amyloid forming hexapeptides. To this end, we expanded our previous set of 280 hexapeptides used to develop the Waltz algorithm with 89 peptides from literature review and by systematic experimental characterisation of the aggregation of 720 hexapeptides by transmission electron microscopy, dye binding and Fourier transform infrared spectroscopy. This brings the total number of experimentally characterized hexapeptides in the WALTZ-DB database to 1089, of which 244 are annotated as positive for amyloid formation.