Exploring Diversity through Dimerization in Natural Products by a Rational Tandem Mass-Based Molecular Network Strateg
Exploring Diversity through Dimerization in Natural Products by a Rational Tandem Mass-Based Molecular Network Strateg
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DOI：
10.1021/acs.orglett.3c01038
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Xianming Deng
中科院分区：
文献类型：
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作者：
Li Li;Yuezhou Wang;Naixin Chen;Xiaoyang Li;Hanpeng Li;Ling Jin;Yixin Ou;Xiang-Jian Kong;Shugeng Cao;Qingyan Xu;Xiaobing Wu;Jianyong Han;Xianming Deng
The step- and atom-efficient dimerization strategy is frequently used in nature to build structural complexity and diversity. We propose the rationale and structural features of the versatile monomers that are responsible for "diversity through dimerization". Using 5-FAM-maleimide combined with a UHPLC-MS/MS-FBMN workflow, we successfully identified a diverse set of dimeric natural products from fungus Panus rudis F01315, in which all four complex 4'5-ring scaffolds are derived from one monomeric epoxyquinol and endowed with functional diversity.
