Effects of rosiglitazone and metformin on postprandial paraoxonase-1 and monocyte chemoattractant protein-1 in human immunodeficiency virus-infected patients with lipodystrophy
Effects of rosiglitazone and metformin on postprandial paraoxonase-1 and monocyte chemoattractant protein-1 in human immunodeficiency virus-infected patients with lipodystrophy
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DOI：
10.1016/j.ejphar.2006.06.014
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发表时间：
2006-08-21
影响因子：
5
通讯作者：
Joven, Jorge
中科院分区：
文献类型：
--
作者：
Coll, Blai;van Wijk, Jeroen P. H.;Joven, Jorge
人类免疫缺陷病毒（HIV）的高效抗逆转录病毒治疗与脂肪代谢障碍、胰岛素抵抗和动脉粥样硬化有关。我们研究了罗格列酮或二甲双胍对患有脂肪代谢障碍的HIV感染男性患者空腹和餐后炎症和抗氧化变量的影响。31名患者被随机分配接受罗格列酮（4 mg，每日两次）或二甲双胍（1 g，每日两次）治疗26周。在基线和治疗后，进行标准化的10小时口服脂肪负荷试验。治疗前，炎症变量保持不变，但餐后高密度脂蛋白（HDL）-胆固醇和对氧磷酶（PON 1）活性降低。罗格列酮和二甲双胍降低稳态模型评估指数（HOMA）相似（分别为-34%和-37%，P < 0.05）。两种治疗均增加空腹和餐后PON 1活性，降低餐后单核细胞趋化蛋白1（MCP-1）浓度。然而，血浆C反应蛋白（CRP）和白细胞介素-6（IL-6）浓度在整个研究过程中没有变化。降低胰岛素抵抗会导致高密度脂蛋白（HDL）的抗氧化作用增强，从而降低促炎症作用。这可能会对这些患者的加速动脉粥样硬化提供保护。(c)2006 Elsevier B. V.保留所有权利。
Highly active antiretroviral therapy in Human Immunodeficiency Virus (HIV) has been associated with lipodystrophy, insulin resistance and atherosclerosis. We investigated the effects of rosiglitazone or metformin on fasting and postprandial inflammatory and antioxidant variables in HIV-infected males with lipodystrophy.Thirty-one patients were randomly assigned to receive either rosiglitazone (4 mg twice daily) or metformin (1 g twice daily) for 26 weeks. At baseline and after treatment, standardized 10-h oral fat loading tests were performed. Before treatment, inflammatory variables remained unchanged but there was a postprandial decrease in high density lipoprotein (HDL)-cholesterol and paraoxonase (PON1) activity. Rosiglitazone and metformin reduced homeostasis model assessment index (HOMA) similarly (-34% and -37%, respectively, P < 0.05 for each). Both treatments increased fasting and postprandial PON1 activity and decreased postprandial monocyte chemoattractant protein 1 (MCP-1) concentrations. However, plasma C-reactive protein (CRP) and Interleukin-6 (IL-6) concentration did not change throughout the study.To decrease insulin resistance results in a higher anti-oxidant and consequent lower pro-inflammatory action of HDL. This may confer protection against accelerated atherosclerosis in these patients. (c) 2006 Elsevier B.V. All rights reserved.