Prevalence and risk factors for multidrug resistant uropathogens in ED patients
Prevalence and risk factors for multidrug resistant uropathogens in ED patients
复制标题
DOI：
10.1016/s0735-6757(00)90005-6
复制
发表时间：
2000-03-01
影响因子：
3.6
通讯作者：
Haas, DW
中科院分区：
文献类型：
--
作者：
Wright, SW;Wrenn, KD;Haas, DW
本研究的目的是描述感染微生物的耐药模式并确定尿路感染患者多药耐药的危险因素。 435 名年龄大于或等于 16 岁的尿路感染患者的回顾性病例系列。多重耐药性定义为对大于或等于两类抗生素的耐药性，收集了人口统计学、历史和微生物学数据。采用单变量分析和多变量逻辑回归确定多重耐药的危险因素，37%的分离株出现多重耐药。单变量分析揭示了与耐药性的许多关联。多变量分析发现三个独立因素与多药耐药性相关：导尿管的使用（比值比 [OR] 2.6，95% 置信区间 [CI] 1.4 至 4.8）、年龄大于或等于 65 岁（OR 3.0，95% CI 1.7 至 5.4）和抗生素使用（OR 4.6，95% CI 2.8 至 7.5）。当排除导尿管患者时，糖尿病也是一个危险因素（OR 2.4，95% CI 1.1 至 5.3），所有组患者均出现耐药，但在老年患者和使用导尿管的患者中尤为常见。抗生素的使用与多重耐药性高度相关。 （Am J Emerg Med 2000；18：143-146。版权所有 (C) 2000，W.B. Saunders Company）。
The purpose of this study was to describe resistance patterns of infecting organisms and determine risk factors for multidrug resistance in patients with urinary tract infections. Retrospective case series of 435 patients age greater than or equal to 16 with urinary tract infection. Multidrug resistance was defined as resistance to greater than or equal to two classes of antibiotics, Demographic, historical, and microbiological data were collected. Univariate analysis and multivariate logistic regression were used to determine risk factors for multidrug resistance, Multidrug resistance was seen in 37% of isolates. Univariate analysis revealed numerous associations with resistance. Multivariate analysis found three independent factors associated with multidrug resistance: urinary catheter use (odds ratio [OR] 2.6, 95% confidence interval [CI] 1.4 to 4.8), age greater than or equal to 65 years (OR 3.0, 95% CI 1.7 to 5.4) and antibiotic use (OR 4.6, 95% CI 2.8 to 7.5). Diabetes was also a risk factor when patients with urinary catheters were excluded (OR 2.4, 95% CI 1.1 to 5.3), Resistance was seen in all groups of patients, but was particularly common in older patients and those who used a urinary catheter. Antibiotic use was highly associated with multidrug resistance. (Am J Emerg Med 2000;18:143-146. Copyright (C) 2000 by W.B. Saunders Company).