Bone lead and blood lead levels in relation to baseline blood pressure and the prospective development of hypertension - The Normative Aging Study
Bone lead and blood lead levels in relation to baseline blood pressure and the prospective development of hypertension - The Normative Aging Study
复制标题
DOI：
10.1093/aje/153.2.164
复制
发表时间：
2001-01-15
影响因子：
5
通讯作者：
Hu, H
中科院分区：
文献类型：
--
作者：
Cheng, YW;Schwartz, J;Hu, H
在1991年至1997年间，作者研究了833名参与规范衰老研究的参与者，研究内容包括骨铅水平（通过k壳x射线荧光测量）、血铅水平和高血压。在这些受试者中，337人在基线时被划分为血压正常，182人和314人分别被划分为边缘性和明确性高血压。这些骨铅和血铅水平是社区暴露男性的典型水平。在519名基线时没有明确高血压病史的受试者中，横断面分析显示收缩压和骨铅水平呈正相关。在474名基线时无明确高血压并有随访资料的受试者中，报告了74例新的明确高血压病例。基线骨铅水平与高血压发病率呈正相关。在控制年龄、年龄平方、体重指数和高血压家族史的比例风险模型中，髌骨（小梁）铅从最低五分位数的中点增加到最高五分位数的中点，与明确高血压的比率为1.71（95%可信区间：1.08,2.70）相关。与血铅水平无关联。这些结果支持了这样的假设，即累积接触铅，即使是普通人群维持在低水平，也可能增加高血压的风险。
Between 1991 and 1997, the authors studied 833 participants of the Normative Aging Study in a substudy of bone lead levels (measured by K-shell x-ray fluorescence), blood lead levels, and hypertension. Among these subjects, 337 were classified as normotensive, and 182 and 314 were classified as having borderline and definite hypertension, respectively, at baseline. These bone and blood lead levels were typical of those of community-exposed men. Among the 519 subjects with no history of definite hypertension at baseline, cross-sectional analyses revealed positive associations between systolic blood pressure and bone lead levels. Of the 474 subjects who were free from definite hypertension at baseline and had follow-up data, 74 new cases of definite hypertension were reported. Baseline bone lead levels were positively associated with incidence of hypertension. In proportional hazards models that controlled for age, age squared, body mass index, and family history of hypertension, an increase in patella (trabecular) lead from the midpoint of the lowest quintile to that of the highest quintile was associated with a rate ratio of definite hypertension of 1.71 (95% confidence interval: 1.08, 2.70). No association was found with blood lead level. These results support the hypothesis that cumulative exposure to lead, even at low levels sustained by the general population, may increase the risk of hypertension.