Lactonamycin, a new antimicrobial antibiotic produced by Streptomyces rishiriensis.
Lactonamycin, a new antimicrobial antibiotic produced by Streptomyces rishiriensis.
复制标题
乳霉素是由利希里链霉菌产生的一种新型抗菌抗生素。
DOI：
--
复制
发表时间：
1996
期刊：
影响因子：
--
通讯作者：
T. Takeuchi
中科院分区：
文献类型：
--
作者：
N. Matsumoto;T. Tsuchida;M. Maruyama;R. Sawa;N. Kinoshita;Y. Homma;Y. Takahashi;H. Iinuma;H. Naganawa;T. Sawa;M. Hamada;T. Takeuchi
自20世纪80年代以来，耐甲氧西林金黄色葡萄球菌（MRSA）在临床上引起了严重的问题。万古霉素和阿贝卡星两种抗mrsa药物在日本临床使用。但最近报道的万古霉素耐药肠球菌（VRE）的出现威胁着那些从事医疗的人。因此，我们致力于从微生物来源发现有效对抗各种细菌的抗生素，包括mrsav和VRE。在我们从土壤微生物中筛选新抗生素的过程中，我们从日本神奈川县横滨市采集的土壤样品中分离出了一种新的抗生素——乳酸霉素(1)1}（图1）。抗生素1对革兰氏阳性菌包括mrsav和VRE均有抑菌活性。在本文中，我们报告了生产菌株的分类，发酵，分离，理化性质和生物学
Methicillin-resistant Staphylococcus aureus (MRSA) has caused a serious problem in clinics since 1980s. Two anti-MRSA agents, vancomycm and arbekacin are used clinically in Japan. But emergence of vancomycinresistant Enterococcus (VRE) reported recently threatened those engaged in medical treatment. So we are devoted to discover antibiotics effective against various bacteria including MRSAand VRE from microbial sources. In the course of our screening from soil microorganisms for new antibiotics, we have isolated a new antibiotic, lactonamycin (1)1} (Fig. 1) from a culture broth of Streptomyces rishiriensis MJ773-88K4 which was isolated from a soil sample collected at Yokohama City, Kanagawa prefecture, Japan. Antibiotic 1 showed antimicrobial activities against Gram-positive bacteria including MRSAand VRE. In this paper, we report the taxonomy of the producing strain, fermentation, isolation, physico-chemical properties and biological pp. 269 275