Invasive pulmonary aspergillosis in neutropenic patients and the influence of hospital renovation
Invasive pulmonary aspergillosis in neutropenic patients and the influence of hospital renovation
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DOI：
10.1111/j.1439-0507.2007.01453.x
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发表时间：
2008-03-01
期刊：
影响因子：
4.9
通讯作者：
Fanci, Rosa
中科院分区：
文献类型：
--
作者：
Pini, Gabriella;Faggi, Elisabetta;Fanci, Rosa
为了评估空气中曲霉菌污染的影响期间和之后的佛罗伦萨血液学单位的装修工作，我们进行了（2003年11月至2005年1月）严格的环境真菌监测计划。空气样本取自病房、病房内沿着走廊、病房间沿着走廊和大楼外。沿着两个血液科病房之间的走廊烟曲霉菌浓度较高（2.98 CFU m（-3）），在非血小板减少患者的房间和医院大楼外较低（分别为1.53和1.42 CFU m（-3）），在血小板减少患者的房间非常低（0.09 CFU m（-3））。在此期间，三个已证实的案件（A。在97例急性白血病患者（7%）中记录了2例可能和2例侵袭性肺曲霉菌病。这三个被证实的曲霉病病例与装修工程期间和我们发现的曲霉菌最高浓度的时期相吻合。熏沿着走廊。这些数据表明，环境真菌污染和侵袭性曲霉病的发病率之间可能存在关系，并强调了环境监测的重要性。
To evaluate the effects of airborne Aspergillus contamination during and after the renovation work of a Florentine haematology unit, we conducted (November 2003-January 2005) a strict programme of environmental fungal surveillance. Air samples were taken from patients' rooms, along the corridors inside the wards, along the corridor between wards and outside the building. The concentration of Aspergillus fumigatus was high along the corridor between the two haematology wards (2.98 CFU m(-3)), lower in the non-neutropenic patients' rooms and outside the hospital building (1.53 and 1.42 CFU m(-3), respectively), very low in the neutropenic patients' rooms (0.09 CFU m(-3)). During this period, three proven cases (A. fumigatus), two probable ones and two possible cases of invasive pulmonary aspergillosis were documented in 97 patients with acute leukaemia (7%). The three cases of proven aspergillosis coincided with the period of renovation work and with the period in which we have found the maximum concentration of A. fumigatus along the corridor. These data suggest a possible relationship between environmental fungal contamination and the incidence of invasive aspergillosis, and underline the importance of environmental surveillance.