Parental regulation of central patterns of estrogen receptor α
Parental regulation of central patterns of estrogen receptor α
复制标题
DOI：
10.1016/j.neuroscience.2006.05.069
复制
发表时间：
2006-09-29
期刊：
影响因子：
3.3
通讯作者：
Cushing, B. S.
中科院分区：
文献类型：
--
作者：
Kramer, K. M.;Carr, M. S.;Cushing, B. S.
杏仁内侧核(Mea)和终纹床核(BST)雌激素受体α(ERα)水平的降低被认为在男性一夫一妻制相关行为的表达中起重要作用。因此，ERα的调节可能是决定男性行为和一夫一妻制演变的关键因素。比较了草原田鼠(Microtus Ochrogaster)两个表型不同种群杂交后代中ERα免疫反应性的中枢表达。伊利诺伊州田鼠(IL)是一夫一妻制的，表现出低水平的ERα，而堪萨斯田鼠(KN)表现出一些与一夫多妻制相关的特征，表现出较高的ERα水平。在杂交后代中，ERα的表达模式取决于亲本；两种类型的杂交在后代中产生的ERα模式不同。在BST和MEA中，杂交雄性表达的ERα模式与其母亲群体中的雄性一致，而杂交雌性具有典型的属于其父亲群体的雌性ERα模式。ERα表达的亲本特异性模式提示了基因组印记，因此，克隆和测序了田鼠ERα(ESR1)基因，并检测了等位基因特异性表达。这项研究的结果表明，虽然母体因素可能对ERα在雄性后代中的表达起主要作用，但基因组印记不太可能参与其中，这表明另一种机制是可能的。(C)2006年IBRO。爱思唯尔有限公司出版。保留所有权利。
Reduced levels of estrogen receptor alpha (ER alpha) in the medial amygdala (MeA) and bed nucleus of stria terminalis (BST) have been hypothesized to play a significant role in the expression of male behaviors associated with monogamy. Therefore, the regulation of ER alpha could be a critical factor in determining male behavior and the evolution of monogamy. Central expression of ER alpha immunoreactivity was compared in hybrid offspring from crosses between two phenotypically distinct populations of prairie voles (Microtus ochrogaster). Illinois voles (IL) are socially monogamous and display low levels of ER alpha, while Kansas voles (KN) display some characteristics associated with polygyny and have higher levels of ER alpha. In offspring from hybrid crosses, the pattern of ER alpha expression was dependent upon parentage; the two types of hybrid crosses did not produce the same ER alpha pattern in the offspring. In the BST and MeA, hybrid males expressed ER alpha patterns consistent with those of males from their mother's population, while hybrid females had ER alpha patterns typical of females belonging to their father's population. The parental-specific patterns of ER alpha expression are suggestive of genomic imprinting, therefore, the vole ER alpha (Esr1) gene was cloned and sequenced, and examined for allele-specific expression. Results from this study indicate that while maternal factors may play a major role the expression of ER alpha in their male offspring, genomic imprinting is unlikely to be involved, suggesting another mechanism is responsible. (c) 2006 IBRO. Published by Elsevier Ltd. All rights reserved.