Alterations of the serum N-glycan profile in female patients with Major Depressive Disorder
Alterations of the serum N-glycan profile in female patients with Major Depressive Disorder
复制标题
DOI：
10.1016/j.jad.2018.02.082
复制
发表时间：
2018-07-01
影响因子：
6.6
通讯作者：
Karabatsiakis, Alexander
中科院分区：
文献类型：
--
作者：
Boeck, Christina;Pfister, Sophia;Karabatsiakis, Alexander
Background: Glycans are short chains of saccharides linked to glycoproteins that are known to be involved in a wide range of inflammatory processes. As depression has been consistently associated with chronic low-grade inflammation, we asked whether patients with Major Depressive Disorder show alterations in the N-glycosylation pattern of serum proteins that might be linked to associated changes in inflammatory processes.Methods: In a study cohort of 21 female patients with an acute depressive episode and 21 non-depressed female control subjects aged between 50 and 69 years, we analyzed the serum N-glycan profile by DNA Sequencer Adapted-Fluorophore Assisted Carbohydrate Electrophoresis (DSA-FACE) and assessed the serum levels of interleukin (IL)-6, tumor necrosis factor (TNF)-alpha and C-reactive protein (CRP) by chemiluminescence immunoassays and nephelometry.Results: Compared to controls, MDD patients showed significant differences in the serum levels of several N-glycan structures. Alterations in the serum N-glycan profile were associated with depressive symptom severity and exploratory analyses revealed that they were most pronounced in MDD patients with a history of childhood sexual abuse. Furthermore, MDD patients showed higher levels of IL-6 and a trend for higher CRP levels, which were also associated with similar alterations in the serum N-glycan profile as those characteristic for MDD patients.Limitations: The relatively small sample size and the presence of potential confounders (e.g., BMI, smoking, medication).Conclusion: The results offer the first evidence that specific differences in the N-glycosylation pattern of serum proteins constitute a so far unrecognized level of biological alterations that might be involved in the immune changes associated with MDD.
