An open source and reduce expenditure ROS generation strategy for chemodynamic/photodynamic synergistic therapy
An open source and reduce expenditure ROS generation strategy for chemodynamic/photodynamic synergistic therapy
复制标题
用于化学动力学/光动力学协同治疗的开源并减少支出的 ROS 生成策略
DOI：
10.1038/s41467-020-15591-4
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发表时间：
2020-04-08
影响因子：
16.6
通讯作者：
Dong, Haifeng
中科院分区：
文献类型：
--
作者：
Liu, Conghui;Cao, Yu;Dong, Haifeng
活性氧（ROS）参与的癌症治疗的治疗效果受到氧底物短缺的显著限制，例如光动力疗法（PDT）中的缺氧和化学动力疗法（CDT）中的过氧化氢（H2 O2）不足。本文报道了一种H2 O2/O-2自供给型纳米药剂（MSNs@CaO2-ICG）@LA，它由硅酸锰（MSN）负载过氧化钙（CaO 2）和吲哚菁绿色（ICG）组成，并进一步对相变材料月桂酸（LA）进行表面修饰。在激光照射下，ICG同时产生单线态氧并释放热量以熔化LA。暴露的CaO 2与水反应产生O-2和H2 O2，用于缺氧缓解的ICG介导的PDT和H2 O2供应的基于MSN的CDT，作为ROS产生的开源策略。此外，MSN诱导的谷胱甘肽耗竭保护ROS免于清除，称为减少消耗。这种开源和减少开支的策略在体外和体内均有效抑制肿瘤生长，并从多个水平显著提高ROS参与的癌症治疗的ROS产生效率。用于动态治疗的氧物质的供应是主要限制。在这里，作者报告了过氧化钙与光/化学动力学试剂的复合物，其中NIR加热导致过氧化钙的释放，以产生用于光动力学和化学动力学治疗的氧气和过氧化氢。
The therapeutic effect of reactive oxygen species (ROS)-involved cancer therapies is significantly limited by shortage of oxy-substrates, such as hypoxia in photodynamic therapy (PDT) and insufficient hydrogen peroxide (H2O2) in chemodynamic therapy (CDT). Here, we report a H2O2/O-2 self-supplying nanoagent, (MSNs@CaO2-ICG)@LA, which consists of manganese silicate (MSN)-supported calcium peroxide (CaO2) and indocyanine green (ICG) with further surface modification of phase-change material lauric acid (LA). Under laser irradiation, ICG simultaneously generates singlet oxygen and emits heat to melt the LA. The exposed CaO2 reacts with water to produce O-2 and H2O2 for hypoxia-relieved ICG-mediated PDT and H2O2-supplying MSN-based CDT, acting as an open source strategy for ROS production. Additionally, the MSNs-induced glutathione depletion protects ROS from scavenging, termed reduce expenditure. This open source and reduce expenditure strategy is effective in inhibiting tumor growth both in vitro and in vivo, and significantly improves ROS generation efficiency from multi-level for ROS-involved cancer therapies. The supply of oxygen species for dynamic therapy is a major limitation. Here, the authors report on a complex of calcium peroxide with photo/chemo dynamic agents, where NIR heating causes the release of calcium peroxide to generate oxygen and hydrogen peroxide for photodynamic and chemodynamic therapy.