Serum resistin correlates with central obesity but weakly with insulin resistance in Chinese children and adolescents
Serum resistin correlates with central obesity but weakly with insulin resistance in Chinese children and adolescents
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DOI：
10.1038/ijo.2009.44
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发表时间：
2009-04-01
影响因子：
4.9
通讯作者：
Cianflone, K.
中科院分区：
文献类型：
--
作者：
Li, M.;Fisette, A.;Cianflone, K.
目的：抵抗素与肥胖有关，除了与急性炎症有关外，还被假设为胰岛素抵抗的潜在标志物。然而，这些联系在人类身上仍然存在很大争议。我们的目标是在大量亚洲儿童和青少年中研究抵抗素水平与肥胖、胰岛素抵抗和炎症标志物的关系。方法：对6-18岁的儿童和青少年（n = 3472），男孩（n = 1765）和女孩（n = 1707）进行体格参数、青春期发育、血脂、血糖、胰岛素、抵抗素、c反应蛋白（CRP）、脂联素和补体C3 （C3）水平的评估。结果：抵抗素随中枢性肥胖而升高，但与男孩单纯性肥胖无关。一些与中心性肥胖相关的标志物与血浆抵抗素呈性别特异性相关。腰围、脂肪质量百分比、腰高比和身体质量指数（BMI）均与抵抗素呈正相关。血脂如甘油三酯、非酯化脂肪酸（NEFA）和低密度脂蛋白胆固醇、舒张压和收缩压与男孩抵抗素呈正相关。NEFA、高密度脂蛋白胆固醇（负）和炎症标志物，如CRP和C3，与女孩抵抗素呈正相关。抵抗素和脂联素之间没有相关性，在男孩和女孩中，脂联素与抵抗素五分之一没有关联。在男孩和女孩中，抵抗素都随着年龄的增长而下降，女孩的抵抗素水平高于男孩。胰岛素抵抗指标与血浆抵抗素的相关性不明显。结论：在该人群中，血浆抵抗素水平是代谢功能障碍的一个弱生化指标，由中枢性肥胖、肥胖和炎症定义，不能预测胰岛素抵抗。只有一小部分抵抗素变异可以用与代谢综合征相关的因素来解释，这表明抵抗素在任何被检查的病理中都不以浓度依赖的方式密切相关。
Objective: Resistin has been linked with obesity and hypothesized as a potential marker of insulin resistance in addition to being linked with acute inflammation. However, these links are still highly controversial in humans. Our goal was to examine resistin levels in relation to obesity, insulin resistance and inflammation markers in a large population of Asian children and adolescents.Methods: Children and adolescents (n = 3472) aged 6-18 years, boys (n = 1765) and girls ( n 1707), were assessed for body size parameters, pubertal development, blood lipids, glucose, insulin, resistin, C-reactive protein (CRP), adiponectin and complement C3 (C3) levels.Results: Resistin increased with central obesity in both genders but not with simple adiposity in boys. Several markers associated with central obesity correlated in a gender-specific fashion with plasma resistin. Waist circumference, fat-mass percentage, waist-to-height ratio and body mass index (BMI) positively correlated with resistin in both genders. Blood lipids such as triglycerides, nonesterified fatty acids (NEFA) and low-density lipoprotein cholesterol, diastolic and systolic blood pressure correlated positively with resistin in boys. NEFA, high-density lipoprotein cholesterol ( negatively) and inflammation markers, such as CRP and C3, positively correlated with resistin in girls. There was no correlation between resistin and adiponectin, and no association of adiponectin with resistin quintiles in either boys or girls. In both boys and girls, resistin tended to decrease with age, with girls having higher levels than boys. Few indices of insulin resistance were linked with plasma resistin in either gender.Conclusion: In this population, plasma resistin levels are a weak biochemical marker of metabolic dysfunction defined by central obesity, adiposity and inflammation and does not predict insulin resistance. Only a small proportion of resistin variation can be explained by factors related to metabolic syndrome, suggesting that resistin is not strongly implicated in a concentration-dependent fashion in any of the examined pathologies.