Age-related changes in locus ceruleus on neuromelanin magnetic resonance imaging at 3 Tesla.
Age-related changes in locus ceruleus on neuromelanin magnetic resonance imaging at 3 Tesla.
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DOI：
10.2463/mrms.5.197
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发表时间：
2006-12-01
期刊：
影响因子：
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通讯作者：
Sakai, Akio
中科院分区：
文献类型：
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作者：
Shibata, Eri;Sasaki, Makoto;Sakai, Akio
目的：应用磁共振神经黑素成像技术研究健康受试者蓝斑的增龄性改变。方法：对健康志愿者(23~80岁)进行神经黑素敏感的T1加权成像，测量蓝斑对应的高信号区的对比度。结果：所有受试者均能在去甲肾上腺素能神经元内识别出代表神经黑素的一对点状高信号区。LC与邻近脑桥被盖的对比度在40~59岁时逐渐增加，在老年组逐渐明显降低。这与病理证实的LC内神经黑素含量与年龄相关的变化有很好的相关性。结论：在确定LC中是否存在异常时，应考虑与年龄相关的差异。
PURPOSE: To investigate age-related changes in the locus ceruleus (LC) in healthy subjects using neuromelanin magnetic resonance (MR) imaging at 3 Tesla.METHODS: We examined 64 healthy volunteers (aged 23 to 80 years) using neuromelanin-sensitive T1-weighted images and measured the contrast of areas of high signal intensity corresponding to the LC.RESULTS: A pair of punctate areas of high signal intensity that represented neuromelanin within the noradrenergic neurons of the LC was easily recognized in all subjects. The contrast ratio of the LC to the adjacent pontine tegmentum increased to the age of 40 to 59 years and gradually and significantly decreased in elderly subjects. This correlates well with pathologically proven age-related changes in neuromelanin content within the LC.CONCLUSION: Age-related variance should be considered when determining the existence of abnormalities in the LC.