Maturation of the human fovea: correlation of spectral-domain optical coherence tomography findings with histology.
Maturation of the human fovea: correlation of spectral-domain optical coherence tomography findings with histology.
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DOI：
10.1016/j.ajo.2012.05.004
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发表时间：
2012-11
影响因子：
4.2
通讯作者：
Toth, Cynthia A.
中科院分区：
文献类型：
--
作者：
Vajzovic, Lejla;Hendrickson, Anita E.;O'Connell, Rachelle V.;Clark, Laura A.;Tran-Viet, Du;Possin, Daniel;Chiu, Stephanie J.;Farsiu, Sina;Toth, Cynthia A.
将光谱域光学相干断层扫描（SDOCT）显示的人类中心凹发育与组织学标本相关联。回顾性、观察性病例系列。将22名早产儿、30名足月婴儿、16名儿童和1名无黄斑疾病的成人各1只眼睛的视网膜SDOCT图像的形态和层厚度与可比年龄的光学显微镜组织学进行比较。SDOCT图像与所有时间点的主要组织学结果相关。使用这两种方法，早产儿表现出一个浅的中央凹凹陷的视网膜内层（IRL）和短，未开发的中央凹光感受器。在足月时，进一步的IRL移位形成小凹，外周光感受器延长;内段和外段（IS和OS，组织学）的延长将IS带与视网膜色素上皮分离。出生后数周内，中心凹IS和OS均短于外周（两种方法）。到13个月时，中心凹视锥细胞体堆叠>6深，Henle纤维层（HFL）增厚，IS/OS长度等于外周;在SDOCT上，中心凹外核层（包括HFL）和IS/OS增厚。在13至16岁，中央凹是充分发展的SDOCT带的完整补充;锥细胞体>10深薄，细长，紧密包装的IS/OS。我们定义解剖相关的SDOCT图像从正常的产前和产后的人类中央凹。由于中央凹视锥的不成熟，成人中央凹的光感受器的典型OCT带在出生时不存在，在24个月时发育，并在儿童期成熟。这验证了SDOCT信号的来源，并提供了一个框架，以评估中央凹的发展和疾病。
To correlate human foveal development visualized by spectral-domain optical coherence tomography (SDOCT) with histologic specimens. Retrospective, observational case series. Morphology and layer thickness of retinal SDOCT images from 1 eye each of 22 premature infants, 30 term infants, 16 children, and 1 adult without macular disease were compared to light microscopic histology from comparable ages. SDOCT images correlate with major histologic findings at all time points. With both methods, preterm infants demonstrate a shallow foveal pit indenting inner retinal layers (IRL) and short, undeveloped foveal photoreceptors. At term, further IRL displacement forms the pit and peripheral photoreceptors lengthen; the elongation of inner and outer segments (IS and OS, histology) separates the IS band from retinal pigment epithelium. Foveal IS and OS are shorter than peripheral for weeks after birth (both methods). By 13 months, foveal cone cell bodies stack >6 deep, Henle fiber layer (HFL) thickens, and IS/OS length equals peripheral; on SDOCT, foveal outer nuclear layer (which includes HFL) and IS/OS thickens. At 13 to 16 years, the fovea is fully developed with a full complement of SDOCT bands; cone cell bodies >10 deep have thin, elongated, and tightly packed IS/OS. We define anatomic correlates to SDOCT images from normal prenatal and postnatal human fovea. OCT bands typical of photoreceptors of the adult fovea are absent near birth because of the immaturity of foveal cones, develop by 24 months, and mature into childhood. This validates the source of SDOCT signal and provides a framework to assess foveal development and disease.
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影响因子：
4.2
作者：
Cabrera, Michelle T.;Maldonado, Ramiro S.;Freedman, Sharon F.
通讯作者：
Freedman, Sharon F.
影响因子：
4.4
作者：
Curcio, Christine A.;Messinger, Jeffrey D.;Spaide, Richard F.
通讯作者：
Spaide, Richard F.
影响因子：
3.9
作者：
HENDRICKSON, A
通讯作者：
HENDRICKSON, A
影响因子：
1.6
作者：
Maldonado, Ramiro S.;Freedman, Sharon F.;Toth, Cynthia A.
通讯作者：
Toth, Cynthia A.
影响因子：
4.2
作者：
Ghazi, NG;Dibernardo, C;Gehlbach, PL
通讯作者：
Gehlbach, PL