Asymmetric Intramolecular Hydroalkoxylation of Unactivated Alkenes Catalyzed by Chiral N‐ Triflyl Phosphoramide and TiCl 4 †
Asymmetric Intramolecular Hydroalkoxylation of Unactivated Alkenes Catalyzed by Chiral N‐ Triflyl Phosphoramide and TiCl 4 †
复制标题
DOI：
10.1002/cjoc.201900544
复制
发表时间：
2020-06
影响因子：
5.4
通讯作者：
Peng Zhao;Aolin Cheng;Xinxu Wang;Jiguo Ma;Guoqing Zhao;Yingkun Li;Yi Zhang;Baoguo Zhao
中科院分区：
文献类型：
--
作者：
Peng Zhao;Aolin Cheng;Xinxu Wang;Jiguo Ma;Guoqing Zhao;Yingkun Li;Yi Zhang;Baoguo Zhao
以手性n -三氟酰磷酰胺和ticl4为催化剂，建立了非活化烯烃分子内不对称氢烷氧基化反应的新工艺，产率为51% ~ 99%，ee′s为30% ~ 71%。
Summary of main observation and conclusionBy using a combination of a chiralN‐triflyl phosphoramide and TiCl4as the catalyst, a new process for asymmetric intramolecular hydroalkoxylation of unactivated alkenes was developed, producing various chiral tetrahydrofuran derivatives in 51%—99% yields with 30%—71% ee's.