Leptin and aging:: Correlation with endocrine changes in male and female healthy adult populations of different body weights
Leptin and aging:: Correlation with endocrine changes in male and female healthy adult populations of different body weights
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DOI：
10.1210/jc.85.5.1954
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发表时间：
2000-05-01
影响因子：
5.8
通讯作者：
Fabbri, A
中科院分区：
文献类型：
--
作者：
Isidori, AM;Strollo, F;Fabbri, A
衰老与几种激素血浆水平的变化有关。关于循环瘦素水平是否会在衰老过程中发生变化，存在相互矛盾的报道，可能的解释是肥胖和体重指数（BMI）也会发生变化。在这项研究中，我们测量了 150 名男性和 320 名女性的血浆瘦素和已知影响瘦素的其他激素参数，这些参数的年龄范围广泛（18-77 岁），BMI 范围广泛（18.5-61.1 kg/m(2)）。每个性别的受试者被分为 BMI 相似的 2 组，即非肥胖组 (BMT，30)，并分别进行治疗。进行统计分析，将每组受试者视为整个群体或分为年龄组（50 岁）。随着女性年龄的增加，经 BMI 调整的瘦素水平逐渐降低，绝经后持续下降（-21%；P < 0.001）；在男性中，50 岁以上的受试者的瘦素水平也往往较低，但降低幅度并不显着。对作为整体或分为肥胖和非肥胖的受试者进行的多元线性回归分析表明，在两种性别中，BMI和年龄都是瘦素水平的独立影响因素，并且在肥胖（女性标准化系数β = -0.25，男性 -0.23；P < 0.01）和非肥胖（女性 -0.22，男性 - 0.20；P < 0.20）和非肥胖者中，瘦素和年龄之间存在负相关关系。 0.05）科目。还评估了瘦素和年龄与性别和甲状腺激素、GH、胰岛素样生长因子 I、PRL 和胰岛素血浆水平的相关性。与瘦素相关的变量包含在包含体重指数和年龄的多元回归模型中。男性睾酮（非肥胖者为 -0.43，肥胖者为 - 0.19；P < 0.05）和女性雌二醇（非肥胖者为 0.22，肥胖者为 0.24；P < 0.05）是瘦素水平的重要贡献者；此外，肥胖女性的硫酸脱氢表雄酮（-0.16）和肥胖男女受试者的性激素结合球蛋白（女性为 0.15，男性为 0.19）是该模型中的重要决定因素。然而，没有一个激素参数消除了瘦素与年龄或瘦素水平的性别差异之间的负相关性。总之，我们的数据表明，在不同体重的成年人中，血清瘦素随着衰老而逐渐下降；女性瘦素减少程度高于男性，但它与体重指数和其他与年龄相关的内分泌变化无关。
Aging is associated with changes in plasma levels of several hormones. There are conflicting reports on whether circulating leptin levels change during aging, the possible explanation for which is that alterations in adiposity and body mass index (BMI) also occur. In this study we measured plasma leptin and other hormonal parameters known to influence leptin in 150 men and 320 women of a wide age (18-77 yr) and BMI (18.5-61.1 kg/m(2)) range. Subjects of each gender were separated into 2 groups of similar BMI, i.e. nonobese (BMT, 30), and treated separately. Statistical analysis was performed, treating each group of subjects as a whole population or divided into age groups (50 yr). BMI-adjusted leptin levels were progressively lower with increasing age in women, with a consistent fall after menopause (-21%; P < 0.001); in men, leptin levels also tended to be lower in subjects more than 50 yr of age, but the reduction was not significant. Multiple linear regression analysis, performed on subjects treated either as a whole population or divided into obese and nonobese, showed that in both genders BMI and age were independent contributors of leptin levels, and there was an inverse relationship between leptin and age in both obese (standardized coefficient beta = -0.25 in women and -0.23 in men; P < 0.01) and nonobese (-0.22 in women and - 0.20 in men; P < 0.05) subjects. The correlation of leptin and age with plasma levels of sex and thyroid hormones, GH, insulin-like growth factor I, PRL, and insulin was also evaluated. The variables that correlated with leptin were included in a multiple regression model that included BMI and age. Testosterone in men (-0.43 in nonobese and - 0.19 in obese; P < 0.05) and estradiol in women (0.22 in nonobese and 0.24 in obese; P < 0.05) were important contributors to leptin levels; also, dehydroepiandrosterone sulfate in obese women (-0.16) and sex hormone-binding globulin in obese subjects of both genders (0.15 in women and 0.19 in men) were significant determinants in the model. However, none of the hormonal parameters abolished the negative correlation between leptin and age or the gender difference in leptin levels. In conclusion, our data show that in adult humans of different body weight;, serum leptin gradually declines during aging; leptin reduction is higher in women than in men, but it is independent hom BMI and other age-related endocrine changes.