A TRANSMISSION AND SCANNING ELECTRON-MICROSCOPIC STUDY OF SURGICALLY EXCISED PRERETINAL MEMBRANE PROLIFERATIONS IN DIABETES-MELLITUS
A TRANSMISSION AND SCANNING ELECTRON-MICROSCOPIC STUDY OF SURGICALLY EXCISED PRERETINAL MEMBRANE PROLIFERATIONS IN DIABETES-MELLITUS
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DOI：
10.1016/0002-9394(82)90241-0
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发表时间：
1982-01-01
影响因子：
4.2
通讯作者：
MACHEMER, R
中科院分区：
文献类型：
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作者：
HAMILTON, CW;CHANDLER, D;MACHEMER, R
采用透射电镜、扫描电镜或两种方法对玻璃体切割术中从糖尿病患者身上切除的视网膜前膜（30）进行了观察。所有标本从眼内取出后仍能正确定位。所有标本均含有不同数量的胶原蛋白，大多数有血管，基板增厚，周围有周细胞。在21个含有血管的膜中，只有4个膜上有开孔毛细血管。膜内散布着多种类型的细胞，包括多形核白细胞、淋巴细胞、浆细胞、巨噬细胞（含黑色素和含铁血黄素）、胶质细胞、视网膜色素上皮细胞和来源不明的细胞。扫描电镜显示，膜的视网膜侧比玻璃侧光滑，并在膜的玻璃侧显示视网膜前细胞，或为单个星状细胞，或为单层扁平细胞，带有微绒毛。从视网膜表面剥离的膜在视网膜一侧有一个光滑的，通常是无细胞的表面。
Preretinal membranes (30), excised from diabetic patients during pars plana vitrectomy, were examined by transmission electron microscopy, scanning electron microscopy or both. All the specimens were still correctly orientated after removal from the eyes. All the specimens contained collagen in varying amounts, and most had blood vessels with a thickened basal lamina and adjacent pericytes. Fenestrated capillaries were identified in only 4 of the 21 membranes containing blood vessels. A wide variety of cell types were scattered within the membrane, including polymorphonuclear leukocytes, lymphocytes, plasma cells, macrophages (containing melanin and hemosiderin), glial cells, retinal pigment epithelium and cells of uncertain derivation. Scanning electron microscopy showed the retinal side of the membranes to be smoother than the vitreal side, and disclosed preretinal cells on the vitreal side of the membranes, either as individual stellate cells or as a monolayer of flattened cells with microvilli. Membranes stripped from the surface of the retina had a smooth, generally acellular surface on the retinal side.