Influence of human immunodeficiency virus infection on chronic hepatitis B in homosexual men
Influence of human immunodeficiency virus infection on chronic hepatitis B in homosexual men
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DOI：
10.1002/hep.510290447
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发表时间：
1999-04-01
期刊：
影响因子：
13.5
通讯作者：
Marcellin, P
中科院分区：
文献类型：
--
作者：
Colin, JF;Cazals-Hatem, D;Marcellin, P
本研究的目的是评估人类免疫缺陷病毒（HIV）感染对慢性B型肝炎的影响。对132例（65例抗-HIV阳性）慢性B肝炎的非吸毒同性恋男性患者进行肝功能生化检测，血清HBV DNA水平和肝组织HBc抗原免疫组化染色检测HBV复制程度，肝组织学活动指数检测肝组织病变程度。抗HIV阳性和抗HIV阴性患者的血清天冬氨酸转氨酶活性、胆红素、凝血酶原和组织学活动指数无差异。抗HIV阳性患者血清丙氨酸转氨酶活性水平较低（P = 0.0001），血清白蛋白水平较低（P = 0.0009），血清HBV DNA水平较高（P = 0.01）。抗HIV阳性患者中肝硬化的患病率较高（P = 0.04）。在患有慢性B型肝炎的男同性恋者中，HIV感染与HBV复制水平较高和肝硬化风险较高相关，但不增加肝脏坏死炎症过程。
The aim of this study was to assess the influence of human immunodeficiency virus (HIV) infection on chronic hepatitis B. Zn a series of 132 (65 anti-HIV positive) homosexual non-drug addicted men with chronic hepatitis B, the liver function was assessed with biochemical tests; the degree of hepatitis B virus (HBV) replication was assessed with serum HBV DNA level and with immunoper-oxidase staining of hepatitis B core (HBc) antigen on liver specimens; and the severity of liver lesions was assessed with an histology activity index. Anti-HIV-positive and anti-HIV-negative patients were not different for serum aspartate transaminase activity, bilirubin, prothrombin, and histology activity index. Anti-HIV-positive patients had lower serum alanine transaminase activity levels (P = .0001), lower serum albumin levels (P = .0009), and higher serum HBV DNA levels (P = .01). There was a higher prevalence of cirrhosis in anti-HIV-positive patients (P = .04). In homosexual men with chronic hepatitis B, HIV infection is associated with a higher level of HBV replication and a higher risk for cirrhosis without increased liver necrotico-inflammatory process.