THE CYTOLOGICAL IDENTITY AND INTERRELATION OF MESENCHYMAL CELLS OF LYMPHOID TISSUE
THE CYTOLOGICAL IDENTITY AND INTERRELATION OF MESENCHYMAL CELLS OF LYMPHOID TISSUE
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DOI：
10.1111/j.1749-6632.1959.tb40796.x
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发表时间：
1958-01-01
影响因子：
5.2
通讯作者：
GALL, EA
中科院分区：
文献类型：
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作者：
GALL, EA
石蜡切片，苏木精伊红染色。不同意其形态特征。我必须承认，我对这些元素的全能性无动于衷，感到一种颤抖的无畏感。分散在牙髓中的其他细胞似乎更有可能具有造血能力。这些细胞比淋巴细胞大得多，细胞质丰富，不清楚，用酸性染料染色苍白。细胞核大，呈球形，轮廓清晰，含有少量染色质，但有明显的核仁（图1）。为了安抚那些容易被激怒的人，人们最好把这些元素指定为"A"或"X"细胞。另一方面，由于它们显然是原始的，具有合生体的特征，并且被许多人认为是构成前体元素的，一个更明确的名称似乎是可取的。如果“网织细胞”这个术语真的有意义的话，有些人会赞成把这些细胞归类为“网织细胞”。正如我将在后面说明的那样，情况并非如此，"干细胞"一词的提出是鉴于细胞的胚胎外观和在许多方面模拟胚胎成血管细胞的细胞学性质。同样常见的是与干细胞稍有相似之处的细胞，有时也会被误认为干细胞，这种细胞也很大，但其细胞质更清晰，而且明显嗜酸性。其核较小，偏心，范围从球形到肾形配置。它的染色质，在不同的字符，只有很少表现出泡状外观。核仁不具有在更原始的元件中看到的突出，并且具有突出的重要性，吞噬细胞-
Paraffin section, hernatoxylin and eosin stain. disagreement as to their morphologic character. I must confess to a sense of tremulous intrepidity at being unimpressed with the totipotentiality of these elements. Other cells sparsely scattered in the pulp appear more likely to have hematopoietic capacities. These are considerably larger than lymphocytes possessing abundant, poorly defined cytoplasm that stains palely with acid dyes. Nuclei are large, spherical, sharply outlined, and contain scanty chromatin, but have characteristically prominent nucleoli (FIGURE 1). In order to assuage those easily ruffled, one would do well to designate these elements as “A” or “X” cells. On the other hand, since they are obviously primitive, have syncitial character, and are considered by many to constitute precursor elements, a more explicit name would seem desirable. It would meet favor with some to classify these cells as “reticulum cells” if this were truly a meaningful term. As I shall show later, this is not the case, and the term “stem cell” is proposed in view of the embryonal appearance of the cell and the cytological qualities which, in many respects, simulate the embryonic angioblast. Also common is a cell that remotely resembles the stem cell and is occasionally mistaken for it. It, too, is large, hut its cytoplasm is more clearly defined and frankly eosinophilic. Its nucleus is smaller, eccentric, and ranges from a spherical to a reniform configuration. Its chromatin, varied in character, only rarely exhibits a vesicular appearance. Nucleoli do not have the prominence seen in the more primitive elements and, of salient importance, phagocytic cyto-