Diagnostic Accuracy of Monofilament Tests for Detecting Diabetic Peripheral Neuropathy: A Systematic Review and Meta-Analysis.
Diagnostic Accuracy of Monofilament Tests for Detecting Diabetic Peripheral Neuropathy: A Systematic Review and Meta-Analysis.
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DOI：
10.1155/2017/8787261
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发表时间：
2017
影响因子：
4.3
通讯作者：
Wang P
中科院分区：
文献类型：
--
作者：
Wang F;Zhang J;Yu J;Liu S;Zhang R;Ma X;Yang Y;Wang P
目的：系统评价单丝试验对糖尿病周围神经病变的诊断准确性。我们检索了EMBASE （OvidSP）、MEDLINE （OvidSP）、Cochrane图书馆和Web of Science，以确定单丝试验检测糖尿病周围神经病变的诊断准确性试验。我们使用分级汇总受试者操作特征（HSROC）模型对单丝试验检测糖尿病周围神经病变的诊断准确性进行荟萃分析。共有19项比较试验符合纳入标准，是定性综合的一部分。选取以神经传导研究为参考标准的8项试验进行meta分析。单丝试验检测糖尿病周围神经病变的总敏感性和特异性分别为0.53（95%可信区间（CI） 0.32 ~ 0.74）和0.88 （95% CI 0.78 ~ 0.94）。合并阳性似然比和阴性似然比分别为4.56 （95% CI 2.93 ~ 7.10）和0.53 （95% CI 0.35 ~ 0.81）。我们的综述表明，单丝试验对筛查糖尿病周围神经病变的敏感性有限。单纤维试验在糖尿病周围神经病变评估中的临床应用基于目前可获得的证据不能被鼓励。
To systematically evaluate the diagnostic accuracy of monofilament tests for detecting diabetic peripheral neuropathy. We searched EMBASE (OvidSP), MEDLINE (OvidSP), the Cochrane Library, and Web of Science to identify diagnostic accuracy trials of monofilament tests for detecting diabetic peripheral neuropathy. We used a hierarchical summary receiver operating characteristics (HSROC) model to conduct the meta-analysis of diagnostic accuracy of monofilament tests for detecting diabetic peripheral neuropathy. A total of 19 comparative trials met the inclusion criteria and were part of the qualitative synthesis. Eight trials using nerve conduction studies as the reference standard were selected for the meta-analysis. The pooled sensitivity and specificity of monofilament tests for detecting diabetic peripheral neuropathy were 0.53 (95% confidence interval (CI) 0.32 to 0.74) and 0.88 (95% CI 0.78 to 0.94), respectively. The pooled positive likelihood ratio and negative likelihood ratio were 4.56 (95% CI 2.93 to 7.10) and 0.53 (95% CI 0.35 to 0.81), respectively. Our review indicated that monofilament tests had limited sensitivity for screening diabetic peripheral neuropathy. The clinical use of the monofilament test in the evaluation of diabetic peripheral neuropathy cannot be encouraged based on currently available evidence.
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影响因子：
3.5
作者：
Bracewell, N.;Game, F.;Scammell, B. E.
通讯作者：
Scammell, B. E.
影响因子：
120.7
作者：
Kanji, Jamil N.;Anglin, Rebecca E. S.;Panju, Akbar
通讯作者：
Panju, Akbar
影响因子：
5.1
作者：
Olaleye, D;Perkins, BA;Bril, V
通讯作者：
Bril, V
影响因子：
16.2
作者：
Lee, C. Christine;Perkins, Bruce A.;Hanley, Anthony J.
通讯作者：
Hanley, Anthony J.
影响因子：
16.2
作者：
Booth, J;Young, MJ
通讯作者：
Young, MJ