Plasma selenium level before diagnosis and the risk of prostate cancer development
Plasma selenium level before diagnosis and the risk of prostate cancer development
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DOI：
10.1016/s0022-5347(05)65500-0
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发表时间：
2001-12-01
影响因子：
6.6
通讯作者：
Carter, HB
中科院分区：
文献类型：
--
作者：
Brooks, JD;Metter, EJ;Carter, HB
目的：流行病学研究和一项随机干预试验表明，摄入硒可以降低前列腺癌的风险。我们调查了诊断前血浆硒水平是否与后期发展为前列腺癌的风险相关。材料和方法：对巴尔的摩老龄化纵向研究登记处的男性进行病例对照研究，包括52例已知前列腺癌患者和96例年龄匹配的未检测到前列腺疾病的对照组。用石墨炉原子吸收分光光度法在前列腺癌诊断前平均时间正负标准差为3.83 +/- 1.85年测定血浆硒。采用logistic回归计算校正优势比和95%置信区间。结果：在诊断、体重指数、吸烟和饮酒史前纠正多年后，高硒与较低的前列腺癌风险相关。与硒含量最低的四分位数（8.2 ~ 10.7 μ g /dl）相比，第二（10.8 ~ 11.8）、第三（11.9 ~ 13.2）和第四（13.3 ~ 18.2）四分位数的比值比分别为0.15（95%可信区间0.05 ~ 0.50）、0.21（0.07 ~ 0.68）和0.24 (0.08 ~ 0.77),p =0.01。此外，血浆硒随着患者年龄的增长而显著下降(p
Purpose: Epidemiological studies and a randomized intervention trial suggest that the risk of prostate cancer may be reduced by selenium intake. We investigated whether plasma selenium level before diagnosis correlated with the risk of later developing prostate cancer.Materials and Methods: A case control study was performed on men from the Baltimore Longitudinal Study of Aging registry, including 52 with known prostate cancer and 96 age matched controls with no detectable prostatic disease. Plasma selenium was measured at an average time plus or minus standard deviation of 3.83 +/- 1.85 years before the diagnosis of prostate cancer by graphite furnace atomic absorption spectrophotometry. Adjusted odds ratio and 95% confidence interval were computed with logistic regression.Results: After correcting for years before diagnosis, body mass index, and smoking and alcohol use history, higher selenium was associated with a lower risk of prostate cancer. Compared with the lowest quartile of selenium (range 8.2 to 10.7 mug./dl.), the odds ratios of the second (10.8 to 11.8), third (11.9 to 13.2) and fourth (13.3 to 18.2) quartiles were 0.15 (95% confidence interval 0.05 to 0.50), 0.21 (0.07 to 0.68) and 0.24 (0.08 to 0.77, respectively, p =0.01). Furthermore, plasma selenium decreased significantly with patient age (p