Scaling deterministic lateral displacement arrays for high throughput and dilution-free enrichment of leukocytes
Scaling deterministic lateral displacement arrays for high throughput and dilution-free enrichment of leukocytes
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DOI：
10.1088/0960-1317/21/5/054024
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发表时间：
2011-05-01
影响因子：
2.3
通讯作者：
Nordon, Robert E.
中科院分区：
文献类型：
--
作者：
Inglis, David W.;Lord, Megan;Nordon, Robert E.
在医学诊断和治疗中，非常需要一种用于将血液分级成其组分的一次性装置，其操作简单并且提供大于1 mL/min（-1）的通量。本文描述了一种具有平行确定性侧向位移装置的用于从血液中富集白细胞的装置。我们显示了98%的捕获率和全血中白细胞的约10倍富集。我们展示了通过集成六个并行设备来实现每大气压每分钟115 μ L未稀释血液的流速。
A disposable device for fractionation of blood into its components that is simple to operate and provides throughput of greater than 1 mL min(-1) is highly sought after in medical diagnostics and therapies. This paper describes a device with parallel deterministic lateral displacement devices for enrichment of leukocytes from blood. We show capture of 98% and approximately ten-fold enrichment of leukocytes in whole blood. We demonstrate scaling up through the integration of six parallel devices to achieve a flow rate of 115 mu L of undiluted blood per minute per atmosphere of applied pressure.