Antinociceptive and anti-inflammatory activities of flower (Alangium salvifolium) extract.
Antinociceptive and anti-inflammatory activities of flower (Alangium salvifolium) extract.
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DOI：
10.3923/pjbs.2013.1040.1045
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发表时间：
2013-10-01
期刊：
影响因子：
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通讯作者：
Nesa, Mst Luthfun
中科院分区：
文献类型：
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作者：
Zahan, Ronok;Nahar, Laizuman;Nesa, Mst Luthfun
研究八角枫花对小鼠的镇痛和抗炎作用。采用小鼠扭体法、醋酸扭体法和福尔马林舔体法测定其镇痛活性。使用角叉菜胶和福尔马林诱导的小鼠足肿胀来评价抗炎作用。AS花甲醇提取物（50和100 mg kg ~（-1））和氯仿提取物（100 mg kg ~（-1））对小鼠福尔马林致痛试验的两个时相均有明显的抑制作用，对醋酸引起的小鼠扭体反应有明显的抑制作用，对热水热刺激引起的小鼠尾热反应有明显的延迟作用。AS的花提取物对角叉菜胶和福尔马林引起的足肿胀也有明显的抑制作用（近50%）。抑制作用类似于吲哚美辛，p.o.不同的生物碱和黄酮类化合物中发现的提取物可以解释的镇痛和抗炎作用。
The present study aimed to evaluate the antinociceptive and anti-inflammatory activity of Alangium salvifolium (AS) flower in mice. The antinociceptive activity was determined using tail immerson, acetic acid induced writhing and formalin induced licking test. Antiinflammatory effects were evaluated using carrageenan and formalin induced paw edema in mice. The methanol extract (50 and 100 mg kg(-1)) of flower of AS followed by chloroform extract (100 mg kg(-1)) produced a significant inhibition of both phases of the formalin pain test in mice, a reduction in mice writhing induced by acetic acid and delayed the response of mice to hot water thermal stimulation in tail immersion test. All flowers extract of AS also produced a substantial inhibition (nearly 50%) of carrageenan and formalin induced paw edema. The inhibitions were similar to those produced by indomethacin, p.o. The different alkaloids and flavonoids found in the extract could be account for the antinociceptive and anti-inflammatory actions.