E-cadherin expression associated with differentiation and prognosis in patients with non-small cell lung cancer
E-cadherin expression associated with differentiation and prognosis in patients with non-small cell lung cancer
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DOI：
10.1016/s0003-4975(00)02545-5
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发表时间：
2001-03-01
影响因子：
4.6
通讯作者：
Yokomise, H
中科院分区：
文献类型：
--
作者：
Liu, DG;Huang, CL;Yokomise, H
Background. E-Cadherin plays a major role in maintaining the intercellular junctions in epithelial tissues. The reduction of E-cadherin expression in cancer cells may be associated with tumor differentiation, metastasis, and a poor prognosis.Methods. Immunohistochemistry for E-cadherin expression was performed on 109 tumors from patients with non-small cell lung cancer who underwent operations.Results. With respect to membranous immunostaining, 57 carcinomas were E-cadherin-positive, 39 carcinomas E-cadherin-reduced, and 13 carcinomas E-cadherin-negative. The percentage of poorly differentiated tumors in the impaired E-cadherin expression group was significantly higher than that in the E-cadherin-positive group (p = 0.005). Furthermore, the frequency of lymph node metastases in tumors with impaired E-cadherin expression was significantly higher than that in the E-cadherin-positive tumors (p = 0.011). A Cox regression analysis revealed that E-cadherin expression was a significant factor in the prediction of survival for patients with non-small cell lung cancer (p = 0.002).Conclusions. E-Cadherin expression was associated with tumor differentiation, lymph node metastasis, and prognosis in patients with non-small cell lung cancer. (C) 2001 by The Society of Thoracic Surgeons.
