Human metabotropic glutamate receptor type 7: Molecular cloning and mRNA distribution in the CNS
Human metabotropic glutamate receptor type 7: Molecular cloning and mRNA distribution in the CNS
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DOI：
10.1016/0169-328x(96)00110-6
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发表时间：
1996-08-01
期刊：
影响因子：
--
通讯作者：
Emson, P
中科院分区：
文献类型：
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作者：
Makoff, A;Pilling, C;Emson, P
从髓质cDNA文库中分离到人代谢性谷氨酸受体7型（mGluR7） cDNA克隆。该序列包含多态性，与大鼠mGluR7具有92%的DNA序列一致性，预测的蛋白序列具有99%的一致性。对人脑切片的原位杂交研究表明，mGluR7 mRNA分布广泛，在海马区、大脑皮层和小脑中表达水平最高。
Human metabotropic glutamate receptor type 7 (mGluR7) cDNA clones were isolated from a medulla cDNA library. The sequence, which includes a polymorphism, has 92% DNA sequence identity with rat mGluR7 and the predicted protein sequence has 99% identity. In-situ hybridization studies on human brain sections showed that mGluR7 mRNA has a widespread distribution with highest levels in the hippocampal formation, cerebral cortex and cerebellum.