Neuropeptides in hypertension: role of neuropeptide Y and calcitonin gene related peptide.
Neuropeptides in hypertension: role of neuropeptide Y and calcitonin gene related peptide.
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DOI：
10.1111/j.1365-2125.1990.tb05472.x
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发表时间：
1990-02
影响因子：
3.4
通讯作者：
T. Westfall;S. Han;M. Knuepfer;J. Martin;X. Chen;K. D. Del Valle;A. Ciarleglio;L. Naes
中科院分区：
文献类型：
--
作者：
T. Westfall;S. Han;M. Knuepfer;J. Martin;X. Chen;K. D. Del Valle;A. Ciarleglio;L. Naes
1.在正常血压的Sprague-Dawley（SD）、Wistar-Kyoto（WKY）和自发性高血压大鼠（SHR）中研究了神经肽Y（NPY）对去甲肾上腺素能轴三个水平心血管功能的影响。2.在灌注的肠系膜动脉床，NPY和结构相似的肽肠多肽（PYY）减少动脉周围神经刺激诱导的NA释放，并加强灌注压力的增加，神经刺激或外源性应用的激动剂（如血管紧张素，加压素，苯肾上腺素）。与NPY和PYY相反，C-末端NPY片段抑制NA释放并产生灌注压的平行降低，从而支持Y1（后）和Y2（前）NPY受体的概念。3.在SHR肠系膜动脉，NPY的连接前抑制作用减弱，连接后反应增强。4.鞘内（Int）注射NPY后，血压、总外周阻力（主要通过肠系膜血管阻力降低）和肾神经活动降低。在SHR中，Int NPY的降压作用减弱。5.下丘脑后核注射神经肽Y可增加血压、后肢和肾血管阻力及肾神经活动。SHR的升压作用增强。6.灌注肠系膜动脉的动脉周围神经刺激产生频率依赖性血管舒张床上预处理与乙啶和预收缩与甲氧胺。（250字处删节）
1. The effect of neuropeptide Y (NPY) on cardiovascular function at three levels of the noradrenergic axis where the peptide is known to co-exist with noradrenaline (NA) and or adrenaline (A) was studied in normotensive Sprague-Dawley (SD), Wistar-Kyoto (WKY) or spontaneously hypertensive rats (SHR). 2. In the perfused mesenteric arterial bed, NPY and the structurally similar peptide intestinal polypeptide (PYY) decreased the periarterial nerve stimulation induced release of NA and potentiated the increase in perfusion pressure to nerve stimulation or exogenously applied agonists (e.g. angiotensin, vasopressin, phenylephrine). In contrast to NPY and PYY, C-terminal NPY fragments inhibited NA release and produced a parallel decrease in perfusion pressure thus supporting the concept of Y1 (post) and Y2 (pre) NPY receptors. 3. In the mesenteric artery of SHR the prejunctional inhibitory effect of NPY was attenuated while the postjunctional response was enhanced. 4. Following intrathecal (Int) injection of NPY, there was a decrease in blood pressure, total peripheral resistance (predominantly by a decrease in mesenteric vascular resistance) and renal nerve activity. The depressor effect of Int NPY was attenuated in the SHR. 5. Unilateral injections of NPY into the posterior hypothalamic nucleus increased blood pressure, hindquarter and renal vascular resistance and renal nerve activity. The pressor effect was enhanced in the SHR. 6. Periarterial nerve stimulation of the perfused mesenteric artery produced a frequency dependent vasodilation in beds pretreated with guanethidine and precontracted with methoxamine.(ABSTRACT TRUNCATED AT 250 WORDS)