Efficient synthesis of α-C-galactosyl ceramide immunostimulants:: Use of ethylene-promoted olefin cross-metathesis
Efficient synthesis of α-C-galactosyl ceramide immunostimulants:: Use of ethylene-promoted olefin cross-metathesis
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DOI：
10.1021/ol0482137
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发表时间：
2004-10-28
期刊：
影响因子：
5.2
通讯作者：
Franck, RW
中科院分区：
文献类型：
--
作者：
Chen, GW;Schmieg, J;Franck, RW
烯烃交叉复分解被用于制备α-C-半乳糖神经酰胺衍生物。歧化过程将乙烯基和丙烯基糖苷与植酸鞘糖苷的乙烯基衍生物结合起来。乙烯的使用提高了甲基化步骤的产率。
Olefin cross-metathesis has been used to prepare alpha-C-galactosylceramide derivatives. The metathesis process merged vinyl and propenyl glycosides with vinyl derivatives of phytosphingosine. The use of ethylene enhanced the yield of the methathesis step.