Design for Gas Chromatography-Corona Discharge-Ion Mobility Spectrometry
Design for Gas Chromatography-Corona Discharge-Ion Mobility Spectrometry
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DOI：
10.1021/ac3025398
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发表时间：
2012-11-20
影响因子：
7.4
通讯作者：
Sherafatmand, Hossein
中科院分区：
文献类型：
--
作者：
Jafari, Mohammad T.;Saraji, Mohammad;Sherafatmand, Hossein
设计并构建了一种新型进样系统的电晕放电电离-离子迁移率光谱仪(CD-IMS)，作为毛细管气相色谱的检测器。在本设计中，使用中空针代替通常用于电晕放电产生的实心针，从而使GC-IMS具有直接的轴向对接。毛细管柱穿过针头，导致流出物与电晕放电电离源上游的反应物离子反应。采用这种样品导入设计，相对于漂移管一侧的入射方向，获得了更高的电离效率。减小了电离区，最大限度地减少了化合物在电离源中的阻力时间，提高了仪器的色谱分辨率。考察了漂移气体流量、补充气体流量、针尖位置等参数的影响。通过分析甲基异丁基酮、庚酮、壬酮和苯乙酮的标准溶液，对所设计的仪器在灵敏度、分辨率和重现性方面进行了详尽的验证。将CD-IMS检测器的检测结果与火焰离子化检测器的检测结果进行了比较，结果表明该GC-IMS具有良好的二维分离能力(基于保留时间和漂移时间信息)和复杂基质中分析物的鉴定能力。
A corona discharge ionization-ion mobility spectrometry (CD-IMS) with a novel sample inlet system was designed and constructed as a detector for capillary gas chromatography. In this design, a hollow needle was used instead of a solid needle which is commonly used for corona discharge creation, helping us to have direct axial interfacing for GC-IMS. The capillary column was passed through the needle, resulting in a reaction of effluents with reactant ions on the upstream side of the corona discharge ionization source. Using this sample introduction design, higher ionization efficiency was achieved relative to the entrance direction through the side of the drift tube. ionization region was reduced to minimize the resistance time of compounds in the ionization source, increasing chromatographic resolution of the instrument. The effects of various parameters such as drift gas flow, makeup gas flow, and column tip position inside the needle were investigated. The designed instrument was exhaustively validated in terms of sensitivity, resolution, and reproducibility by analyzing the standard solutions of methyl isobutyl ketone, heptanone, nonanone, and acetophenone as the test compounds. The results obtained by CD-IMS detector were compared with those of the flame ionization detector, which revealed the capability of the proposed GC-IMS for two-dimensional separation (based on the retention time and drift time information) and identification of an analyte in complex matrixes.