Mechanical surface waves accompany action potential propagation
Mechanical surface waves accompany action potential propagation
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DOI：
10.1038/ncomms7697
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发表时间：
2015-03-01
影响因子：
16.6
通讯作者：
Machta, Benjamin B.
中科院分区：
文献类型：
--
作者：
El Hady, Ahmed;Machta, Benjamin B.
许多不同的研究表明，轴突膜的机械位移伴随着定义动作电位（AP）的电脉冲。我们提出了一个由表面波模式驱动引起的机械位移模型，其中势能存储在神经元膜和细胞骨架的弹性特性中，而动能则由轴浆液携带。在我们的模型中，这些表面波由表征 AP 的电去极化行波驱动，改变跨膜的静电压缩力。这种驱动导致共同传播的机械位移，我们称之为作用波（AW）。我们的模型使我们能够估计伴随任何电压行波的电波的形状，做出与多个实验系统的结果一致的预测。我们的模型可以作为理解这些自动波的物理起源和可能的功能作用的框架。
Many diverse studies have shown that a mechanical displacement of the axonal membrane accompanies the electrical pulse defining the action potential (AP). We present a model for these mechanical displacements as arising from the driving of surface wave modes in which potential energy is stored in elastic properties of the neuronal membrane and cytoskeleton while kinetic energy is carried by the axoplasmic fluid. In our model, these surface waves are driven by the travelling wave of electrical depolarization characterizing the AP, altering compressive electrostatic forces across the membrane. This driving leads to co-propagating mechanical displacements, which we term Action Waves (AWs). Our model allows us to estimate the shape of the AW that accompanies any travelling wave of voltage, making predictions that are in agreement with results from several experimental systems. Our model can serve as a framework for understanding the physical origins and possible functional roles of these AWs.