Racial differences in Helicobacter pylori, serum pepsinogen and gastric cancer incidence in an urban Asian population
Racial differences in Helicobacter pylori, serum pepsinogen and gastric cancer incidence in an urban Asian population
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DOI：
10.1111/j.1440-1746.2005.03898.x
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发表时间：
2005-10-01
影响因子：
4.1
通讯作者：
Tan, J
中科院分区：
文献类型：
--
作者：
Ang, TL;Fock, KM;Tan, J
背景：在新加坡，中国人胃癌发病率最高（C），马来人（M）和印度人（I）发病率较低。本论文的目的是研究是否种族差异的幽门螺杆菌和血清胃蛋白酶原（PG）的患病率可以解释这种difference.Methods：一个随机的社区健康调查，涉及7000名无症状的健康人进行。在中国人、马来人和印度人受访者中，受试者的年龄、性别和种族相匹配，共获得595份血清。螺杆pylori血清阳性和血清PG水平通过ELISA测定。胃溃疡累积发病率与H。pylori血清阳性率用线性回归法评价。H. pylori感染和低血清PG水平。中国人和印度人的pylori血清阳性率相似，但马来人的pylori血清阳性率明显较低（C，46.3%; M，27.9%; I，48.1%）。胃癌发病率与H.中国和马来受试者的幽门螺杆菌血清阳性，但印度受试者没有。印度受试者中低PG的患病率最高（PG I低：C，2.1%; M，5.4%; I，14.2%; P < 0.0001; PG I：II比率低：C，5.3%; M，5.9%; I，12.6%; P = 0.012），即使调整了性别和H的存在。结论：胃癌发病率的差异与H.中国人和马来人受试者的幽门螺杆菌血清阳性率。印度受试者胃癌发病率较低不能用H。其他修饰因素如宿主和环境因素可能也很重要。(C)2005年Blackwell Publishing Asia Pty Ltd.
Background: In Singapore, the highest incidence of gastric cancer occurs in the Chinese (C), with lower rates among Malay (M) and Indian (I) subjects. The purpose of the present paper was to examine whether racial differences in the prevalence of Helicobacter pylori and serum pepsinogen (PG) could account for this difference.Methods: A randomized community health survey involving 7000 asymptomatic healthy individuals was conducted. Among the Chinese, Malay and Indian respondents, subjects were matched for age, gender and race and a total of 595 sera were obtained. The H. pylori seropositivity and serum PG levels were determined by ELISA. The dependency of the cumulative gastric incidence rate on H. pylori seroprevalence was evaluated by linear regression. The racial difference in the seroprevalence of H. pylori and low serum PG was determined.Results: The H. pylori seroprevalence was similar between Chinese and Indian subjects, but significantly lower among Malay subjects (C, 46.3%; M, 27.9%; I, 48.1%). The gastric cancer incidence rates correlated with H. pylori seropositivity for the Chinese and Malay subjects, but not for the Indian subjects. The prevalence of low PG was highest in Indian subjects (PG I low: C, 2.1%; M, 5.4%; I, 14.2%; P < 0.0001; PG I:II ratio low: C, 5.3%; M, 5.9%; I, 12.6%; P = 0.012), even when adjusted for gender and the presence of H. pylori.Conclusions: The difference in gastric cancer incidence correlated with H. pylori seroprevalence for Chinese and Malay subjects. The lower incidence of gastric cancer among Indian subjects cannot be explained by differences in H. pylori or serum PG. Other modifying factors such as host and environmental factors may be important. (C) 2005 Blackwell Publishing Asia Pty Ltd.