Molecular diversity of K+ channels
Molecular diversity of K+ channels
复制标题
DOI：
10.1111/j.1749-6632.1999.tb11293.x
复制
发表时间：
1999-01-01
期刊：
影响因子：
--
通讯作者：
Rudy, B
中科院分区：
文献类型：
--
作者：
Coetzee, WA;Amarillo, Y;Rudy, B
K+通道主要亚基是迄今为止最大和最多样的离子通道。这种多样性部分源于编码K+通道主要亚基的大量基因，但也来自其他过程，如选择性剪接，从单个基因产生多个mRNA转录本，不同主要亚基的异构体组装，以及可能的RNA编辑和翻译后修饰。在这一章中，我们试图(主要以表格的形式)概述K+通道主亚基和辅助亚基的不同编码基因及其谱系关系，讨论不同主亚基与天然K+通道的可能相关性，主要亚基在异源表达系统中表达时形成的通道的生物物理和药理学特性，以及它们的组织表达模式。此外，我们还专门用一节描述了K+通道的多样性是如何通过异构体形成、辅助亚基、选择性剪接、RNA编辑和翻译后修饰来实现的。我们相信，这些事实的收集将对那些试图将新亚基的性质与已知的其他亚基的性质进行比较的人或那些对原生通道和克隆候选通道之间的比较感兴趣的人有用。
K+ channel principal subunits are by far the largest and most diverse of the ion channels. This diversity originates partly from the large number of genes coding for K+ channel principal subunits, but also from other processes such as alternative splicing, generating multiple mRNA transcripts from a single gene, heteromeric assembly of different principal subunits, as well as possible RNA editing and posttranslational modifications. In this chapter, we attempt to give an overview (mostly in tabular format) of the different genes coding for K+ channel principal and accessory subunits and their genealogical relationships, We discuss the possible correlation of different principal subunits with native K+ channels, the biophysical and pharmacological properties of channels formed when principal subunits are expressed in heterologous expression systems, and their patterns of tissue expression, In addition, we devote a section to describing how diversity of K+ channels can be conferred by heteromultimer formation, accessory subunits, alternative splicing, RNA editing and posttranslational modifications, We trust that this collection of facts will be of use to those attempting to compare the properties of new subunits to the properties of others already known or to those interested in a comparison between native channels and cloned candidates.