Inflammation-initiating illnesses, inflammation-related proteins, and cognitive impairment in extremely preterm infants.
Inflammation-initiating illnesses, inflammation-related proteins, and cognitive impairment in extremely preterm infants.
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DOI：
10.1016/j.bbi.2012.12.012
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发表时间：
2013-03
期刊：
影响因子：
--
通讯作者：
ELGAN Study Investigators
中科院分区：
文献类型：
--
作者：
O'Shea TM;Shah B;Allred EN;Fichorova RN;Kuban KCK;Dammann O;Leviton A;ELGAN Study Investigators
新生儿炎症与围产期脑损伤有关。我们评估了炎症相关蛋白的血液水平升高在多大程度上补充了炎症相关疾病提供的早期认知功能受损风险的信息。从800名婴儿出生前28周的怀孕，我们收集了血点在第1，7和14天，25炎症相关蛋白的分析，和数据培养阳性菌血症，坏死性小肠结肠炎（贝尔阶段IIIb），孤立的肠穿孔，在前两周，以及他们是否在出生后第14天通气。如果一种蛋白质的浓度在相隔一周的两天内都处于前四分位数（胎龄和采血日），我们认为该蛋白质是持续或复发性升高。我们在2岁时用贝利智力发育指数（MDI）对这些儿童进行了评估。第14天NEC和通气的组合以及第14天菌血症和通气的组合一致地提供了关于MDI <55的风险升高的信息，无论模型中是否包括蛋白质浓度升高的变量。以下蛋白质浓度持续或反复升高的变量提供了MDI <55风险增加的额外信息：CRP、SAA、IL-6、TNF-α、IL-8、MIP-1 β、ICAM-1、E-SEL和IGFBP-1。我们的结论是，炎症相关蛋白的血药浓度升高提供了2岁时认知功能受损风险的信息，补充了炎症相关疾病提供的信息。
Neonatal inflammation is associated with perinatal brain damage. We evaluated to what extent elevated blood levels of inflammation-related proteins supplement information about the risk of impaired early cognitive function provided by inflammation-related illnesses. From 800 infants born before the 28th week of gestation, we collected blood spots on days 1, 7 and 14, for analysis of 25 inflammation-related proteins, and data about culture-positive bacteremia, necrotizing enterocolitis (Bell stage IIIb), and isolated perforation of the intestine, during the first two weeks, and whether they were ventilated on postnatal day 14. We considered a protein to be persistently or recurrently elevated if its concentration was in the top quartile (for gestational age and day blood was collected) on two separate days one week apart. We assessed the children at 2 years of age with the Bayley Mental Development Index (MDI). The combinations of NEC and ventilation on day 14, and of bacteremia and ventilation on day 14 consistently provided information about elevated risk of MDI <55, regardless of whether or not a variable for an elevated protein concentration was included in the model. A variable for a persistently or recurrently elevated concentration of each of the following proteins provided additional information about an increased risk of MDI <55: CRP, SAA, IL-6, TNF-alpha, IL-8, MIP-1beta, ICAM-1, E-SEL, and IGFBP-1. We conclude that elevated blood concentrations of inflammation-related proteins provide information about the risk of impaired cognitive function at age 2 years that supplements information provided by inflammation-associated illnesses.
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影响因子：
2.1
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