OCULAR SURFACE CHANGES AND DISCOMFORT IN PATIENTS WITH MEIBOMIAN GLAND DYSFUNCTION
OCULAR SURFACE CHANGES AND DISCOMFORT IN PATIENTS WITH MEIBOMIAN GLAND DYSFUNCTION
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DOI：
10.1001/archopht.1995.01100100054027
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发表时间：
1995-10-01
影响因子：
--
通讯作者：
TSUBOTA, K
中科院分区：
文献类型：
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作者：
SHIMAZAKI, J;SAKATA, M;TSUBOTA, K
目的：确定睑板腺功能障碍 (MGD) 对眼表的重要性。设计：前瞻性研究。设置：以大学为基础的转诊实践。患者：对有眼部不适（147 只眼睛）和无眼部不适（54 只眼睛）的患者进行检查。在总共 201 只眼睛中，MGD 被定义为存在睑板孔阻塞（阻塞组 [n=54]）或不存在腺体结构（腺体脱落组 [n=36]），或同时存在这两种情况（组合组 [n=38]）。 73只眼（非MGD组）未发现任何MGD。主要结果指标：通过荧光素和孟加拉玫瑰染色、泪膜破裂石灰、泪液蒸发和泪液产生率以及睑板腺描记术获得分数。结果：在147只眼部不适的眼睛中，95只眼（64.6%）有孔口阻塞或腺体脱落，或两者兼而有之。与非 MGD 组相比，联合组的荧光素 (P=.002) 和玫瑰红 (P=.021) 染色得分更高。腺体脱落组的泪液产生率比非 MGD 组增加更多 (P=.002)。腺体脱落组泪液蒸发率显着增加（P=.017）。结论：睑板腺功能障碍是眼表异常和眼部不适的主要原因。
Objective: To determine the importance of meibomian gland dysfunction (MGD) on the ocular surface.Design: Prospective study.Setting: A university-based referral practice.Patients: Patients with ocular discomfort (147 eyes) and without ocular discomfort (54 eyes) were examined. In the total 201 eyes, MGD was defined as the presence of an obstruction of the meibomian orifices (obstruction group [n=54]) or the absence of a gland structure (gland dropout group [n=36]), or both of these findings (combined group [n=38]). There were not any findings of MGD in 73 eyes (non-MGD group).Main Outcome Measures: Scores that were obtained from fluorescein and rose bengal staining, the breakup lime of the tear film, the rates of tear evaporation and tear production, and meibography.Results: Of the 147 eyes with ocular discomfort, 95 (64.6%) had either an obstruction of an orifice or gland dropout, or both. The combined group had higher scores for staining with fluorescein (P=.002) and rose bengal (P=.021) compared with that in the non-MGD group. The rate of tear production was increased more in the gland dropout group than in the non-MGD group (P=.002). The rate of tear evaporation was significantly increased in the gland dropout group (P=.017).Conclusion: Meibomian gland dysfunction is a major cause of ocular surface abnormalities and ocular discomfort.