Tail-anchored protein biosynthesis at the endoplasmic reticulum: the same but different
Tail-anchored protein biosynthesis at the endoplasmic reticulum: the same but different
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DOI：
10.1042/bst0320659
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发表时间：
2004-11-01
影响因子：
3.9
通讯作者：
Abell, BM
中科院分区：
文献类型：
--
作者：
High, S;Abell, BM
尾部锚定蛋白在内质网上的翻译后整合代表了膜蛋白合成的一条新的和独特的途径。以突触素和细胞色素b5为例，对各种前体的研究表明，多种途径可能促进它们的生物合成。有明确的证据表明，胞质因子和膜成分都促进了至少一些尾部锚定蛋白的有效膜插入。然而，这些介体的性质目前尚不清楚，它们的鉴定将是确定尾部锚定蛋白生物发生的分子基础的关键一步。
The post-translational integration of tail-anchored proteins at the endoplasmic reticulum represents a novel and distinct pathway for membrane protein synthesis. Studies of various precursors, exemplified by the synaptobrevins and cytochrome b5, indicate that multiple routes may facilitate their biosynthesis. There is clear evidence that both cytosolic factors and membrane components facilitate the efficient membrane insertion of at least some tail-anchored proteins. However, the nature of these mediators is currently unknown and their identification will be an essential step in defining the molecular basis of tail-anchored protein biogenesis.