Renal nerve activity and renal function during environmental stress in DOCA-NaCl rats.
Renal nerve activity and renal function during environmental stress in DOCA-NaCl rats.
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DOCA-NaCl 大鼠环境应激期间的肾神经活动和肾功能。
DOI：
10.1152/ajpregu.1986.251.2.r289
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
DiBona,GF
中科院分区：
文献类型：
--
作者：
Koepke,JP;Jones,S;DiBona,GF
在清醒的醋酸去氧皮质酮-氯化钠（DOCA-NaCl）高血压大鼠、假DOCA-NaCl正常血压大鼠和去肾神经DOCA-NaCl大鼠中研究了应激环境刺激（空气应激）对平均动脉压、心率、肾交感神经活动和肾功能的影响。在清醒的DOCA-NaCl高血压大鼠中，空气应激降低尿流率[从17.9 +/- 3.0微升X min-1 X 100 g体重-1（BW）降低36%]，尿钠排泄（39%，3.1 +/- 0.5 microeq X min-1 X 100 g BW-1），水分排泄分数（从4.72 +/- 1.00%到24%）和钠排泄分数（从5.72 +/- 1.08%增加28%）和肾交感神经活动增加（8.3 +/- 0.6积分器复位/min时为94%），而肾小球滤过率无明显变化（0.40 +/- 0.06 ml X min-1 X 100 g BW-1时为-15%）或有效肾血浆流量（2.50 +/- 0.53 ml X min-1 X 100 g BW-1时为-7%）。在清醒的假DOCA-NaCl血压正常大鼠或DOCA-NaCl大鼠肾去神经，空气应激对这些措施没有影响。这三组的平均动脉压和心率不受空气压力的影响。去肾神经支配降低DOCA-NaCl大鼠的基线平均动脉压。因此，DOCA-NaCl高血压大鼠对环境应激的反应是肾交感神经活动增加，因此，抗利尿和抗尿潴留。
The effects of a stressful environmental stimulus (air stress) on mean arterial pressure, heart rate, renal sympathetic nerve activity, and renal function were studied in conscious deoxycorticosterone acetate-sodium chloride (DOCA-NaCl) hypertensive rats, sham DOCA-NaCl normotensive rats, and DOCA-NaCl rats with renal denervation. In conscious DOCA-NaCl hypertensive rats, air stress decreased urine flow rate [36% from 17.9 +/- 3.0 microliter X min-1 X 100 g body wt-1 (BW)], urinary sodium excretion (39% from 3.1 +/- 0.5 microeq X min-1 X 100 g BW-1), fractional water excretion (24% from 4.72 +/- 1.00%), and fractional sodium excretion (28% from 5.72 +/- 1.08%) and increased renal sympathetic nerve activity (94% from 8.3 +/- 0.6 integrator resets/min), but no changes occurred in glomerular filtration rate (-15% from 0.40 +/- 0.06 ml X min-1 X 100 g BW-1) or effective renal plasma flow (-7% from 2.50 +/- 0.53 ml X min-1 X 100 g BW-1). Air stress had no effect on these measures in conscious sham DOCA-NaCl normotensive rats or DOCA-NaCl rats with renal denervation. Mean arterial pressure and heart rate were unaffected by air stress in these three groups. Renal denervation lowered base-line mean arterial pressure in DOCA-NaCl rats. Thus DOCA-NaCl hypertensive rats respond to environmental stress with increased renal sympathetic nerve activity and, consequently, antidiuresis and antinatriuresis.