Development of diabetic complications despite the absence of growth hormone in a patient with post-pancreatectomy diabetes.
Development of diabetic complications despite the absence of growth hormone in a patient with post-pancreatectomy diabetes.
复制标题
尽管胰腺切除术后糖尿病患者缺乏生长激素，但仍会出现糖尿病并发症。
DOI：
10.1056/nejm198403293101307
复制
发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Davis,TQ
中科院分区：
文献类型：
--
作者：
Rabin,D;Bloomgarden,ZT;Feman,SS;Davis,TQ
1953年，鲍尔森描述了一位患有糖尿病的患者，产后脑垂体梗塞后视网膜病变得到改善。1他指出，他的病人所发生的事件可能与豪赛的观察类似，即动物的实验性糖尿病是通过垂体切除术来改变的。2鲍尔森告诫不要将他的观察推断到临床领域。1然而，提出了一些假设，即某些脑垂体因子，可能是生长激素，可能与糖尿病视网膜病变的发病机制有关。3在接下来的20年里，数百名糖尿病患者接受了某种形式的治疗，旨在消除或减少脑垂体功能。3尽管这是一个有益的效果。
IN 1953 Poulsen described a patient with diabetes mellitus in whom retinopathy was ameliorated after postpartum pituitary infarction.1He pointed out the possible analogy of the events in his patient to the observation of Houssay that experimental diabetes in animals was modified by hypophysectomy.2Poulsen cautioned against extrapolating his observations to clinical areas.1Nevertheless, the hypothesis was advanced that some pituitary factor, possibly growth hormone, might be implicated in the pathogenesis of diabetic retinopathy.3Over the next two decades, many hundreds of diabetic patients underwent some form of therapy designed to ablate or reduce pituitary function.3Although a beneficial effect . . .