Mycobacterium xenopi Genotype Associated with Clinical Phenotype in Lung Disease
Mycobacterium xenopi Genotype Associated with Clinical Phenotype in Lung Disease
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DOI：
10.1007/s00408-018-0087-9
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发表时间：
2018-04-01
期刊：
影响因子：
5
通讯作者：
Jamieson, Frances B.
中科院分区：
文献类型：
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作者：
Hirama, Takashi;Marchand-Austin, Alex;Jamieson, Frances B.
爪蟾分枝杆菌是欧洲和加拿大肺部疾病 (PD) 的罪魁祸首。尽管其患病率很高且临床重要性日益增加，但人们对蟾蜍分枝杆菌的遗传多样性知之甚少。通过对蟾蜍分枝杆菌菌株类型及其与临床表型关系的前瞻性研究，对 39 名蟾蜍分枝杆菌 PD 患者进行了分析。我们的研究表明，在安大略省，序列类型 (ST) 5 在 15 种不同的 ST 中占主导地位，即使没有潜在的肺部疾病，也会在人群中引起 PD，而非 ST5 引起的疾病几乎只在患有潜在肺部疾病的患者中发现。
Mycobacterium xenopi is responsible for pulmonary disease (PD) in Europe and Canada. Despite its high prevalence and increasing clinical importance, little is known about the genetic diversity of M. xenopi. Through a prospective study for M. xenopi strain type and the relation to clinical phenotype, 39 patients with M. xenopi PD were analyzed. Our study demonstrated that sequence type (ST) 5 was dominant in Ontario among 15 distinct STs and caused PD in people even without underlying lung disease, whereas disease due to non-ST5 was found almost exclusively in patients with underlying lung disease.