Signet ring cell mixed histology may show more aggressive behavior than other histologies in early gastric cancer
Signet ring cell mixed histology may show more aggressive behavior than other histologies in early gastric cancer
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DOI：
10.1002/jso.23261
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发表时间：
2013-02-01
影响因子：
2.5
通讯作者：
Noh, Sung Hoon
中科院分区：
文献类型：
--
作者：
Huh, Cheal Wung;Jung, Da Hyun;Noh, Sung Hoon
背景胃印戒细胞癌（SRC）与非SRC相比具有不同的显微镜和生物学特征。病理报告部分记录了SRC成分和主要组织学类型。但SRC合剂的临床意义尚未见报道。目的探讨早期胃癌混合型SRC组织学的临床病理特征。方法对2208例早期胃癌患者进行手术治疗。将患者分为腺癌伴部分SRC组（混合SRC组）、单纯腺癌组（腺癌组）和SRC组（SRC组）。比较其临床病理特征。结果与腺癌组相比，SRC组患者年龄小、女性多、中等身材、局限于黏膜、凹陷型、淋巴结转移率低、淋巴管浸润率低、生存率高。混合型SRC组与SRC组相似，与腺癌组相比，与年轻、女性、上身和抑郁类型有关。然而，混合SRC组表现出更多的粘膜下浸润，更大的尺寸，和更高的LNM比其他组。混合SRC成分是LNM的独立危险因素之一。结论EGC中混合型SRC组织比其他组织表现出更强的攻击行为。混合SRC组织学的临床考虑可能有助于决定特定的癌症治疗。外科肿瘤学杂志2013;107：124129. (c)2012 Wiley Periodicals，Inc.
Background Signet ring cell carcinoma (SRC) of the stomach is known to have different microscopic and biologic characteristics compared to non-SRC. The pathologic report has documented partly SRC component with main histologies. However, the clinical significance of SRC mixture has not been reported. Aim was to investigate clinicopathologic features of mixed-SRC histology in early gastric cancer (EGC). Methods Two thousand two hundred eight patients were diagnosed with EGC and underwent surgery. The patients were divided into three groups such as adenocarcinoma with partly SRC (mixed-SRC group), only adenocarcinoma (adenocarcinoma group), and SRC (SRC group). Clinicopathologic characteristics were compared. Results The SRC group was more associated with younger age, female, mid-body, mucosa-confined, depressed type, lower lymph node metastasis (LNM), lower lymphovascular invasion, and better survival rate than adenocarcinoma group. The mixed-SRC group was more associated with younger age, female, upper-body, and depressed type than adenocarcinoma group, similar to SRC group. However, the mixed-SRC group showed more submucosal invasion, larger size, and higher LNM than other groups. The mixed-SRC component was one of the independent risk factors of LNM. Conclusions Mixed-SRC histology in EGC showed more aggressive behavior than other histologies. Clinical considerations of mixed-SRC histology may be helpful to decide on a specific cancer treatment. J. Surg. Oncol. 2013;107:124129. (c) 2012 Wiley Periodicals, Inc.