Radial versus tangential migration of neuronal clones in the developing cerebral cortex.
Radial versus tangential migration of neuronal clones in the developing cerebral cortex.
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DOI：
10.1073/pnas.92.25.11323
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发表时间：
1995-12
影响因子：
11.1
通讯作者：
P. Rakic
中科院分区：
文献类型：
--
作者：
P. Rakic
The cerebral cortex is a striking example of an ingenious and economic design of nature. Although the surface area of the neocortex is vastly different in the wide variety ofmammals, the consistent feature of the cortex is its organization into horizontal and vertical arrays of neurons that form anatomically and physiologically distinct laminar and columnar compartments (1, 2). The application of a variety of neurobiological methods in the past two decades has provided the basis for a formulation of the dynamic cellular principles underlying cortical development (for review, see ref. 3). All cortical neurons in primates, including humans, are generated during the first half of gestation within the proliferative zone lining the surface of.the cerebral ventricle (4). After their final mitotic division, cortical neurons migrate away from the place of their origin, toward the pial surface, where each successive generation passes one another and settles in an inside-out pattern within the cortical plate (5). This sequential pattern is particularly pronounced in the large convoluted primate cerebrum, where migratory pathways are long and tortuous (3). Postmitotic neurons during their migration tend to selectively follow the membrane surface of elongated nonneuronal, radial glial fascicles that transiently span fetal cerebral wall (6). This finding led to the concept of differential neuron-glial cell adhesion and stimulated a search for the molecular mechanisms underlying directed neuronal migration (7, 8). It also led to the formulation of radial unit hypothesis of cortical development.
