Angiotensin-converting enzyme and angiotensinogen gene polymorphisms and heart rate variability in twins
Angiotensin-converting enzyme and angiotensinogen gene polymorphisms and heart rate variability in twins
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DOI：
10.1016/s0002-9149(97)01019-9
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发表时间：
1998-03-15
影响因子：
2.8
通讯作者：
Luft, FC
中科院分区：
文献类型：
--
作者：
Busjahn, A;Voss, A;Luft, FC
心率变异性（HRV）降低与充血性心力衰竭、心肌梗死后、室性心律失常、心源性猝死和年龄增长有关。血管紧张素转换酶（ACE）基因的缺失/插入多态性和血管紧张素原基因的替换（M235T）与心脏病的风险相关。本研究的目的是确定单卵和双卵双生子的HRV和相关参数的遗传度，并评估ACE和血管紧张素原多态性的影响。我们研究了95个MZ对和46个DZ对。我们测量了心率变异性和相关参数，血管紧张素转换酶和血管紧张素原水平，血浆去甲肾上腺素，血管紧张素转换酶和血管紧张素原基因型。我们发现，心率变异性和相关参数显着影响遗传变异性，虽然非共享遗传效应也很重要。血管紧张素原和血浆去甲肾上腺素通常与HRV降低相关，而ACE与正常节律的HRV紊乱相关。然而，DD ACE基因型与HRV增加相关（p
Decreased heart rate variability (HRV) is associated with congestive heart failure, post-myocardial infarction, ventricular arrhythmias, sudden cardiac death, and advancing age. A deletion/insertion polymorphism in the angiotensin-converting enzyme (ACE) gene and a substitution (M235T) in the angiotensinogen gene have been associated with risk for heart disease. The aim of this study was to determine the heritability of HRV and related parameters in monozygotic and dizygotic twins and to assess the influence of ACE and angiotensinogen polymorphisms. We studied 95 MZ pairs and 46 DZ pairs. We measured HRV and related parameters, ACE and angiotensinogen levels, plasma norepinephrine, ACE, and angiotensinogen genotypes. We found that HRV and related parameters were significantly influenced by genetic variability, although nonshared genetic effects were also important. Angiotensinogen and plasma norepinephrine were generally correlated with decreased HRV, whereas ACE was correlated with perturbances of normal rhythmic HRV. Nevertheless, the DD ACE genotype was associated with increased HRV (p