Follow-up investigations of tau protein and S-100B levels in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease
Follow-up investigations of tau protein and S-100B levels in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease
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DOI：
10.1159/000084708
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发表时间：
2005-01-01
影响因子：
2.4
通讯作者：
Otto, M
中科院分区：
文献类型：
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作者：
Cepek, L;Steinacker, P;Otto, M
背景：S-100 B和tau蛋白在克雅氏病（Creutzfeldt-Jakob disease，CJD）的诊断中具有较高的鉴别诊断价值。到目前为止，只有有限的信息，这些参数在脑脊液（CSF）的动力学。然而，人们特别感兴趣的是寻找生化标志物来监测疾病进展，以进行鉴别诊断和治疗。患者和方法：我们分析了45例CJD患者和45例其他神经系统疾病患者的CSF中tau蛋白和S-100 B的随访情况。所有CJD的诊断后来都得到了神经病理学的证实。计算tau蛋白差异与腰椎穿刺间隔时间之间的比值。S-100 B也是如此。结果：34例患者第一次脑脊液标本中Tau蛋白水平高于CJD的临界值（>1,300 pg/ml）。在第一份CSF样本中tau水平较低的11名患者中，有7名患者的tau水平升高。CJD组的上述比率明显高于其他神经系统疾病组。对于S-100 B获得了类似的结果。结论：我们认为随访调查和比值计算是一个有用的工具，在CJD的鉴别诊断。在单个病例中观察到这种模式的变化。版权所有（C）2005 S. Karger AG，巴塞尔。
Background: S-100B and tau protein have a high differential diagnostic potential for the diagnosis of Creutzfeldt-Jakob disease (CJD). So far there has been only limited information available about the dynamics of these parameters in the cerebrospinal fluid (CSF). However, there is a special interest in finding biochemical markers to monitor disease progression for differential diagnosis and treatment. Patients and Methods: We analyzed CSF of 45 patients with CJD and of 45 patients with other neurological diseases for tau protein and S-100B in a follow-up setting. All diagnoses of CJD were later neuropathologically verified. A ratio between tau protein differences and the time between lumbar puncture was calculated. The same was done for S-100B. Results: Tau protein levels of 34 cases were above the cut-off level for CJD (>1,300 pg/ml) in the first CSF sample. In 7 of 11 patients with lower tau levels in the first CSF sample, tau levels rose. The above-mentioned ratio was significantly higher in the CJD group than in the group with other neurological diseases. Similar results were obtained for S-100B. Conclusion: We conclude that follow-up investigations and calculation of ratios is a useful tool in the differential diagnosis of CJD. Variations in this pattern were observed in single cases. Copyright (C) 2005 S. Karger AG, Basel.