The antidepressant fluoxetine restores plasticity in the adult visual cortex
The antidepressant fluoxetine restores plasticity in the adult visual cortex
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DOI：
10.1126/science.1150516
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发表时间：
2008-04-18
期刊：
影响因子：
56.9
通讯作者：
Maffei, Lamberto
中科院分区：
文献类型：
--
作者：
Maya-Vetencourt, Jose Fernando;Sale, Alessandro;Maffei, Lamberto
我们研究了氟西汀（一种广泛用于治疗抑郁症的处方药）是否能恢复成年大鼠视觉系统的神经元可塑性。我们发现，长期给予氟西汀恢复成年期的眼优势可塑性，并促进成年弱视动物的视觉功能的恢复，作为测试的电生理和行为。这些作用伴随着皮质内抑制的减少和视皮质中脑源性神经营养因子表达的增加。皮质给药地西泮防止氟西汀诱导的影响，表明皮质内抑制的减少促进了成人视觉皮层的可塑性。我们的研究结果表明，氟西汀在弱视的潜在临床应用，以及抗抑郁药的治疗效果和情绪障碍的病理生理学的新机制。
We investigated whether fluoxetine, a widely prescribed medication for treatment of depression, restores neuronal plasticity in the adult visual system of the rat. We found that chronic administration of fluoxetine reinstates ocular dominance plasticity in adulthood and promotes the recovery of visual functions in adult amblyopic animals, as tested electrophysiologically and behaviorally. These effects were accompanied by reduced intracortical inhibition and increased expression of brain- derived neurotrophic factor in the visual cortex. Cortical administration of diazepam prevented the effects induced by fluoxetine, indicating that the reduction of intracortical inhibition promotes visual cortical plasticity in the adult. Our results suggest a potential clinical application for fluoxetine in amblyopia as well as new mechanisms for the therapeutic effects of antidepressants and for the pathophysiology of mood disorders.