Quantitative bone scintigraphy: usefulness in the survey of patients treated for bone metastasis of prostatic cancer.
Quantitative bone scintigraphy: usefulness in the survey of patients treated for bone metastasis of prostatic cancer.
复制标题
定量骨闪烁扫描：在调查接受前列腺癌骨转移治疗的患者中的有用性。
DOI：
10.1159/000473431
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发表时间：
1988
期刊：
影响因子：
23.4
通讯作者：
C. Bollack
中科院分区：
文献类型：
--
作者：
Grob Jc;C. Lallot;G. Methlin;C. Bollack
本研究的目的是开发一种定量骨密度成像（QBS）方法，以评估治疗播散性前列腺癌患者骨转移的演变。通过注射99 mTc-亚甲基二膦酸盐后的全身骨显像获得的数据使我们能够定义三个指标，GR，R1和R2。它们分别代表保留在骨中、转移部位和与骨骼整体活性相关的病理部位中的活性量。重复QBS已进行了59例前列腺癌骨转移与激素治疗。QBS的结果与临床发现，特别是疼痛的演变有很好的相关性。此外，QBS的计算指数使得有可能区分三组患者根据激素治疗下的病变的消退、稳定或演变。QBS是评价前列腺癌骨转移疗效的一项敏感而有用的指标。
The purpose of this study was to develop a quantitative bone scintigraphy (QBS) method in order to evaluate the evolution of bone metastases in patients treated for disseminated prostatic cancer. Data obtained by whole body scintigraphy after injection of 99mTc-methylene diphosphonate enabled us to define three indexes, GR, R1 and R2. They respectively represent the amount of activity retained in the bones, in the metastatic sites and in pathological sites related to the global activity of the skeleton. Repeated QBSs have been performed on 59 patients with prostatic carcinoma treated for bone metastasis with hormonal therapy. Results of QBS are well correlated to clinical findings, particularly pain evolution. In addition, the calculated indexes of QBS made it possible to distinguish three groups of patients according to regression, stabilization or evolution of their lesions under hormonal therapy. QBS seems to be a sensitive and useful test for the evaluation of the therapeutic efficiency on bone metastases from prostatic carcinoma.