Airway Smooth Muscle Hypertrophy and Hyperplasia in Asthma
Airway Smooth Muscle Hypertrophy and Hyperplasia in Asthma
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DOI：
10.1164/rccm.201110-1849oc
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发表时间：
2012-05-15
影响因子：
24.7
通讯作者：
Green, Francis H.
中科院分区：
文献类型：
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作者：
James, Alan L.;Elliot, John G.;Green, Francis H.
基本原理：哮喘患者气道平滑肌（ASM）层增厚可能是由于平滑肌细胞增生、肥大或细胞外基质（ECM）增加所致，目的：探讨ASM肥大、ASM增生和ECM沉积与哮喘严重程度和病程的关系。对对照组（n = 51）、非致死性（n = 49）和致死性（n = 55）哮喘病例的气道进行了尸检。估计平均ASM细胞体积（V-c）、每长度气道的ASM细胞数（N-L）和ASM层内细胞外基质的体积分数（f（ECM））。在一般线性回归模型的基础上进行了受试者组之间的比较。测量和主要结果：与对照组相比，非致命性哮喘（P = 0.015）和致命性哮喘（P < 0.001）病例的大气道平均Vc增加。非致死性病例和对照组的N-L相似，但与对照组和非致死性病例相比，致死性哮喘病例的大（P <0.001）、中（P < 0.001）和小（P = 0.034）气道的N-L增加（大和中气道，P <0.001）。
Rationale: Increased thickness of the airway smooth muscle (ASM) layer in asthma may result from hyperplasia or hypertrophy of muscle cells or increased extracellular matrix (ECM).Objectives: To relate ASM hypertrophy, ASM hyperplasia, and deposition of ECM to the severity and duration of asthma.Methods: Airways from control subjects (n = 51) and from cases of nonfatal (n = 49) and fatal (n = 55) asthma were examined postmortem. Mean ASM cell volume (V-c), the number of ASM cells per length of airway (N-L), and the volume fraction of extracellular matrix (f(ECM)) within the ASM layer were estimated. Comparisons between subject groups were made on the basis of general linear regression models. Measurements and Main Results: Mean Vc was increased in the large airways of cases of nonfatal asthma (P = 0.015) and fatal asthma (P < 0.001) compared with control subjects. N-L was similar in nonfatal cases and control subjects but increased in large (P < 0.001), medium (P < 0.001), and small (P = 0.034) airways of cases of fatal asthma compared with control subjects and with nonfatal cases (large and medium airways, P