The sarcomeric cytoskeleton: who picks up the strain?
The sarcomeric cytoskeleton: who picks up the strain?
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DOI：
10.1016/j.ceb.2010.12.001
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发表时间：
2011-02-01
影响因子：
7.5
通讯作者：
Gautel, Mathias
中科院分区：
文献类型：
--
作者：
Gautel, Mathias
在横纹肌肌节中，收缩肌动蛋白和肌球蛋白丝由一组专门的细胞骨架蛋白（肌节细胞骨架）组织而成。它们包括α-肌动蛋白、肌球蛋白以及巨蛋白肌联蛋白、暗蛋白和星云蛋白，它们结合了结构、机械和信号传导功能。肌节的力学和信号传导似乎紧密地相互依赖，但各种肌节细胞骨架蛋白对菌株处理或信号传导的确切贡献才刚刚出现。细胞骨架力学和信号传导的一般机制可以从作为专门的肌动球蛋白系统的肌节中收集。最近的工作深入了解了肌节蛋白复合物的相互作用、结构和机械稳定性，这些蛋白复合物同时发挥结构和信号作用。
In striated muscle sarcomeres, the contractile actin and myosin filaments are organised by a subset of specialised cytoskeletal proteins, the sarcomeric cytoskeleton. They include a-actinin, myomesin, and the giant proteins titin, obscurin and nebulin, which combine architectural, mechanical and signalling functions. Mechanics and signalling in the sarcomere appear tightly interdependent, but the exact contributions of the various sarcomeric cytoskeleton proteins to strain handling or signalling are only just emerging. General mechanisms of cytoskeletal mechanics and signalling may be gleaned from the sarcomere as a specialised actomyosin system. Recent work has led to insight into the interactions, structure, and mechanical stability of sarcomeric protein complexes that fulfil both structural and signalling roles.