A highly active and easily recoverable chitosan@copper catalyst for the C-S coupling and its application in the synthesis of zolimidine
A highly active and easily recoverable chitosan@copper catalyst for the C-S coupling and its application in the synthesis of zolimidine
复制标题
一种高活性、易回收的壳聚糖@铜C-S偶联催化剂及其在唑亚胺合成中的应用
DOI：
10.1039/c4gc00161c
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发表时间：
2014-01-01
期刊：
影响因子：
9.8
通讯作者：
Zhang, Pengfei
中科院分区：
文献类型：
--
作者：
Shen, Chao;Xu, Jun;Zhang, Pengfei
利用壳聚糖水悬浮液与铜盐简单搅拌制备了一种高活性、易回收的多相铜催化剂，合成了芳基砜。chitosan@copper催化剂催化芳基卤化物与亚硫酸钠的偶联反应，很容易得到相应的砜，收率很高。高活性催化剂可以多次重复使用而不失去催化活性。此外，用该方法可以很容易地合成市售药物唑咪定（抗溃疡药）。
Aryl sulfones were synthesized using a highly active and easily recoverable heterogeneous Cu catalyst which was prepared by simply stirring an aqueous suspension of chitosan in water with copper salts. The chitosan@copper catalyst catalyzed the coupling reactions of aryl halides with sodium sulfinates to readily give the corresponding sulfones in good to excellent yields. The highly active catalyst can be reused many times without losing its catalytic activity. In addition, by using this protocol, the marketed drug zolimidine (antiulcer) could be synthesized easily.