Polychlorinated biphenyl levels in the tissues of exposed and nonexposed humans.
Polychlorinated biphenyl levels in the tissues of exposed and nonexposed humans.
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DOI：
10.1289/ehp.94102s1149
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发表时间：
1994-01
影响因子：
10.4
通讯作者：
Chisholm, B
中科院分区：
文献类型：
--
作者：
Schecter, A;Stanley, J;Boggess, K;Masuda, Y;Mes, J;Wolff, M;Furst, P;Furst, C;Wilson-Yang, K;Chisholm, B
多氯联苯（PCBs）是一种合成化学品，从1929年到1970年代大量生产。多氯联苯的环境污染已在各种物质中得到证实，包括人体组织。已通过各种分析方法对人体组织中的多氯联苯进行了测量。多氯联苯含量是以商用混合物中多氯联苯总含量的近似值来报告的，方法是对色谱峰进行鉴定和定量，或对特定同系物进行定性和定量表征。直到最近，共面单邻位和二邻位取代的多氯联苯，这是特别有毒的，目前在人类中的显着浓度从工业国家，尚未在人体组织中测量。在一般人群受试者和经历特殊暴露的人员中提供了各种常用分析的示例。在本文中，PCB的血液测定潜在的暴露后的有用性进行了论证，并说明了它们在健康研究中的应用，从一些案例研究。本文介绍了人类血液中的共面多氯联苯、单邻位取代和二邻位取代多氯联苯水平，并与美国人口中的多氯二恶英和多氯二苯并呋喃水平进行了比较。计算并比较了两组化学品的二恶英毒性当量。据发现，单邻位取代，并在较小程度上，共面多氯联苯，大大有助于二恶英毒性当量（TEq）在血液中的美国成年人。由于多氯联苯对二恶英毒性当量的贡献很大，只有测量二恶英、二苯并呋喃和二恶英类多氯联苯，才能确定二恶英类总毒性。（400字处截断摘要）
Polychlorinated biphenyls (PCBs) are synthetic chemicals, manufactured in volume from about 1929 to the 1970s. Environmental contamination by PCBs has been documented in various substances, including human tissue. PCBs have been measured in human tissue by a variety of analytical methods. PCB levels have been reported as an approximation of total PCB content expressed in terms of a commercial mixture, by identification and quantification of chromatographic peaks, or by qualitative and quantitative characterization of specific congeners. Until recently, the coplanar mono-ortho- and di-ortho substituted PCBs, which are especially toxic and present in significant concentration in humans from industrial countries, had not been measured in human tissues. Examples of various types of commonly used analyses are presented in general population subjects and in persons who experienced special exposure. In this paper, the usefulness of PCB blood determinations following potential exposure is demonstrated, and their application in health studies is illustrated from a number of case studies. Coplanar PCB, mono-ortho-substituted and di-ortho-substituted PCB levels in human blood are presented and compared with polychlorinated dioxin (PCDD) and polychlorinated dibenzofuran (PCDF) levels in the U.S. population. Dioxin toxic equivalents for the two groups of chemicals are calculated and compared. It is found that mono-ortho-substituted and, to a lesser extent, coplanar PCBs, contribute substantially to dioxin toxic equivalents (TEq) in blood from U.S. adults. Because of substantial PCB contribution to dioxin toxic equivalents, total dioxinlike toxicity can only be determined if dioxins, dibenzofurans, and dioxinlike PCBs are measured.(ABSTRACT TRUNCATED AT 400 WORDS)