Intravenous hyperalimentation as an adjunct to cancer chemotherapy with 5-fluorouracil.
Intravenous hyperalimentation as an adjunct to cancer chemotherapy with 5-fluorouracil.
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静脉营养过度作为 5-氟尿嘧啶癌症化疗的辅助手段。
DOI：
10.1016/0022-4804(75)90108-0
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发表时间：
1975
期刊：
影响因子：
--
通讯作者：
S. Dudrick
中科院分区：
文献类型：
--
作者：
E. Souchon;E. Souchon;E. Copeland;E. Copeland;Patti Watson;Patti Watson;S. Dudrick;S. Dudrick
In a series of 30 male Sprague-Dawley rats fed orally, the LD-80 dosage of 5-FU was determined to be 15 mg/kg/day for 7 days. When this dosage was given to a series of rats nourished entirely parenterally by intravenous hyperalimentation, there was a lower incidence of gastrointestinal toxicity, and the mean survival rate was twice that obtained in the orally fed group.In a pilot series of 10 cachectic human beings with metastatic adenocarcinoma of the colon, who were treated simultaneously with 5-FU and intravenous hyperalimentation, the incidence of gastrointestinal side effects was significantly reduced, tolerance to 5-FU per unit time was doubled, and response rate (50% reduction in measurable tumor mass) was 40%, which is greater than that usually reported in comparable patients fed by mouth.
