Role of the prenatal environment in the development of obesity
Role of the prenatal environment in the development of obesity
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DOI：
10.1016/s0022-3476(98)70302-6
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发表时间：
1998-05-01
影响因子：
5.1
通讯作者：
Dietz, WH
中科院分区：
文献类型：
--
作者：
Whitaker, RC;Dietz, WH
确定产前是肥胖发展的关键或敏感期，可能会将基础研究和临床预防工作的重点放在这一时期。这篇综述总结了宫内环境影响日后肥胖风险的证据，并考虑了可能发生这种情况的机制。出生体重和成人体重之间的关联表明，宫内环境对日后肥胖风险有持久的影响。我们研究了糖尿病、肥胖和妊娠体重增加的母体因素是否改变了宫内环境，从而增加了后代日后肥胖的风险。在这些母体因素中，最有力的证据证明了母体糖尿病的作用。没有一种单一的机制可以解释这些母体因素如何改变宫内环境，从而增加肥胖风险。然而，所有潜在的机制都涉及母亲和胎儿之间代谢底物的改变转移，这可能会影响参与能量代谢的器官的发育结构或功能。
Establishing that prenatal life is a critical or sensitive period for the development of obesity may focus basic research and clinical prevention efforts on this period. This review summarizes evidence that the intrauterine environment influences the risk of later obesity and considers the mechanisms by which this may occur. The association between birth weight and adult weight suggests that there are enduring effects of the intrauterine environment on later obesity risk. We examine whether the maternal factors of diabetes, obesity, and pregnancy weight gain alter the intrauterine environment and thereby increase the risk of later obesity in the offspring. Of these maternal factors, evidence is strongest for the role of maternal diabetes. No single mechanism explains how these maternal factors could change the intrauterine environment to increase obesity risk. However, all potential mechanisms involve an altered transfer of metabolic substrates between mother and fetus, which may influence the developing structure or function of the organs involved in energy metabolism.