PRENATAL EFFECTS OF TRICHLORFON ON THE GUINEA-PIG BRAIN
PRENATAL EFFECTS OF TRICHLORFON ON THE GUINEA-PIG BRAIN
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DOI：
10.1007/bf00263954
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发表时间：
1986-05-01
影响因子：
6.1
通讯作者：
FONNUM, F
中科院分区：
文献类型：
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作者：
BERGE, GN;NAFSTAD, I;FONNUM, F
有机磷化合物敌百虫二甲酯(2，2，2-三氯-1-羟乙基)膦酸二甲酯在两个不同孕期(36、37、38天和51、52、53天)经胃管给药(100 mg/kg)。幼崽出现了运动障碍，尸检显示，与对照组相比，总脑和小脑的重量显著减轻。体重也显著减轻，特别是延髓，以及海马体、丘脑和丘脑。小脑组织学检查显示外颗粒层和分子层减少，区域缺乏浦肯野细胞。小脑神经递质酶胆碱乙酰转移酶(ChAT)和谷氨酸脱羧酶(GAD)活性较对照组降低。
The organophosphorus compound trichlorfon, dimethyl (2,2,2-trichloro-1-hydroxyethyl) phosphonate, was administered by stomach tube (100 mg/kg) to pregnant guinea pigs at two different stages of gestation (days 36, 37, 38 and 51, 52, 53). The pups developed locomotory disturbances, and post mortem examination revealed significantly decreased weights of the total brain and the cerebellum, as compared to controls. There was also a significant weight reduction particularly of the medulla oblongata, but also of the hippocampus, the thalamus, and the colliculi. Histological examination of the cerebellum revealed reduction of the external granular layer and the molecular layer, and regional absence of Purkinje cells. The activities of the neurotransmitter enzymes choline acetyltransferase (ChAT), and glutamate decarboxylase (GAD) in cerebellum were reduced as compared to the control values.